Tissue-Engineered Cardiac Constructs for Cardiac Repair

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Presentation transcript:

Tissue-Engineered Cardiac Constructs for Cardiac Repair Shigeru Miyagawa, MD, PhD, Matthias Roth, MD, Atsuhiro Saito, PhD, Yoshiki Sawa, MD, PhD, Sawa Kostin, PhD The Annals of Thoracic Surgery Volume 91, Issue 1, Pages 320-329 (January 2011) DOI: 10.1016/j.athoracsur.2010.09.080 Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Diagram shows the method for engineering the cell sheets. Cell sheets harvested from a temperature-responsive culture dish can be layered to construct a 3-dimensional cardiac graft. (PIPAAm = poly(N-isopropylacrylamide.) The Annals of Thoracic Surgery 2011 91, 320-329DOI: (10.1016/j.athoracsur.2010.09.080) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Possible regeneration mechanisms in myoblast sheet implantation Myoblast sheets are proposed to preserve the left ventricular (LV) geometry, provide elastic tissue to a stiffened scar, and cause cytokine (HGF, SDF-1 etc) release. These cytokines may help restore cytoskeletal proteins, reduce fibrosis, increase angiogenesis, and promote cell migration to the damaged myocardium. These effects may induce improved regional diastolic function, leading to improved systolic function. Solid lines indicate evidence provided by published reports. Dotted lines indicate theoretical mechanisms. (HGF = hepatocyte growth factor; SDF-1= stromal cell-derived factor 1.) The Annals of Thoracic Surgery 2011 91, 320-329DOI: (10.1016/j.athoracsur.2010.09.080) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions