Fertility and Sterility

Slides:

Advertisements

Similar presentations

Copyright © 2009 American Medical Association. All rights reserved.

Advertisements

Treatment of Severe Postmenopausal Endometriosis With an Aromatase Inhibitor 4 Kazuto Takayama, Khaled Zeitoun, Robert T Gunby, Hironobu Sasano, Bruce.

Endometrial bleeding in hormone replacement therapy users: preliminary findings regarding the role of matrix metalloproteinase 9 (MMP-9) and tissue inhibitors.

Augmented epithelial multidrug resistance–associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A4 Ilaria Gori, Ph.D., Yoima.

Sachiko Matsuzaki, M. D. , Takashi Murakami, M. D. , Shigeki Uehara, M

Proteolytic tailoring of the heat shock protein 70 and its implications in the pathogenesis of endometriosis Nina Chehna-Patel, M.Sc., Neeta Warty, M.D.,

Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients

Fertility and Sterility

Increased expression of macrophage colony–stimulating factor and its receptor in patients with endometriosis Nicole M. Budrys, M.D., M.P.H., Hareesh.

Possible involvement of signal transducer and activator of transcription-3 in cell–cell interactions of peritoneal macrophages and endometrial stromal.

Interleukin-17 and Prostaglandin E2 Are Involved in Formation of an M2 Macrophage- Dominant Microenvironment in Lung Cancer Lunxu Liu, MD, PhD, Dongxia.

Tracheal regeneration: Evidence of bone marrow mesenchymal stem cell involvement Agathe Seguin, MD, PhD, Sonia Baccari, MD, Muriel Holder-Espinasse, MD,

Glycodelin A is expressed differentially in normal human endometrial tissue throughout the menstrual cycle as assessed by immunohistochemistry and in.

Brett McKinnon, Ph. D. , Nick A. Bersinger, Ph. D. , Alexander W

Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity Petra A.B. Klemmt, D.Phil.,

Cytokine microenvironments in human first trimester decidua are dependent on trophoblast cells Ulrike von Rango, PhD, Irmgard Classen-Linke, PhD, Gabie.

Michelle Nisolle, M. D. , Ph. D. , Françoise Casanas-Roux, B. S

Modulation of the expression of tissue plasminogen activator and its inhibitor by hypoxia in human peritoneal and adhesion fibroblasts Ghassan M Saed,

Human uterine and ovarian expression of growth hormone–releasing hormone messenger RNA in benign and malignant gynecologic conditions Omid Khorram, M.D.,

Expression of microtubule associated protein 2 and synaptophysin in endometrium: high levels in deep infiltrating endometriosis lesions Martina Gori,

Khaleque Newaz Khan, M. D. , Ph. D. , Michio Kitajima, M. D

Regine Gaetje, M. D. , Uwe Holtrich, Ph. D. , Thomas Karn, Ph. D

In situ localization and quantification of seventy-two – kilodalton type IV collagenase in aneurysmal, occlusive, and normal aorta William D. McMillan,

Fertility and Sterility

Interleukin-18 system messenger RNA and protein expression in human endometrium during the menstrual cycle Hong-Yuan Huang, M.D., She-Hung Chan, B.Sc.,

Retinoic acid suppresses growth of lesions, inhibits peritoneal cytokine secretion, and promotes macrophage differentiation in an immunocompetent mouse.

Dioxin may promote inflammation-related development of endometriosis

Erik Mandelin, M. D. , Hannu Koistinen, Riitta Koistinen, Ph. D

Lusine Aghajanova, M. D. , Ph. D. , Signe Altmäe, Ph. D

Kathryn Smith, M. D. , Redab Alnifaidy, Qingxiang Wei, M. A

Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis Mariela Bilotas, Ph.D., Gabriela.

Xiao-Yu Pan, Ph. D. , Xue Li, M. D. , Zhan-Ping Weng, Ph. D

Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental.

Immunohistochemical detection of heparanase-1 expression in eutopic and ectopic endometrium from women with endometriosis Xiulong Xu, Ph.D., Jianchi.

Up-regulation of endocrine gland-derived vascular endothelial growth factor but not vascular endothelial growth factor in human ectopic endometriotic.

Effect of pentoxifylline on vascular endothelial growth factor C and flk-1 expression on endometrial implants in the rat endometriosis model Nikos F.

Differential interleukin-6 messenger ribonucleic acid expression and its distribution pattern in eutopic and ectopic endometrium Ali Salmassi, Ph.D.,

Parthenolide reduces cell proliferation and prostaglandin estradiol synthesis in human endometriotic stromal cells and inhibits development of endometriosis.

Basal and cytokine-stimulated production of epithelial neutrophil activating peptide-78 (ENA-78) and interleukin-8 (IL-8) by cultured human endometrial.

Murat Ulukus, M. D. , E. Cagnur Ulukus, M. D. , Ege N

Excessive ovarian response is associated with increased expression of interleukin-2 in the periimplantation endometrium Guneet Makkar, Ph.D., Ernest.

Nina Chehna-Patel, M. Sc. , Geetanjali Sachdeva, Ph. D

Ching-wen Cheng, Ph. D. , Stephen K. Smith, M. D. , D

Pasquale Florio, M. D. , Ph. D. , Paulo B. Torres, M. D

Qiong-Hua Chen, Ph. D. , Wei-Dong Zhou, Ph. D. , De-Min Pu, M. D

Aimee S. Browne, M. D. , M. Sc. , Jie Yu, M. D. , M. Sc

Peroxisome proliferator-activated receptor-γ ligand reduced tumor necrosis factor-α- induced interleukin-8 production and growth in endometriotic stromal.

Characterization of messenger RNA expression of estrogen receptor-α and -β in patients with ovarian endometriosis Sachiko Matsuzaki, M.D., Takao Fukaya,

Fei Wang, M. D. , Ph. D. , Zeqing Wen, M. D. , Hui Li, Ph. D

Role of cytokines in endometriosis

Induction of monocyte chemotactic protein-1 in peritoneal mesothelial and endometrial cells by oxidized low-density lipoprotein and peritoneal fluid from.

Alterations in expression of endometrial endothelial nitric oxide synthase and αvβ3 integrin in women with endometriosis Omid Khorram, M.D., Ph.D., Bruce.

Effect of hormonal agents on monocyte chemotactic protein-1 expression by endometrial epithelial cells of women with endometriosis Annie Boucher, M.S.,

Role of endocrine status and cell type in adhesion of human endometrial cells to the peritoneum in nude mice Aude Beliard, M.D., Agnes Noël, Ph.D., Frederic.

Effects of mifepristone on expression of endothelial nitric oxide synthase in human endometrium during the implantation phase Xiaoxi Sun, M.D., Xiaoyan.

Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis Tetsuya Hirata, M.D., Ph.D., Yutaka.

Lin Mu, Ph. D. , Wei Zheng, Ph. D. , M. D. , Liang Wang, Ph. D

Decreased levels of interleukin-18 in peritoneal fluid but not in serum of patients with endometriosis Xinmei Zhang, M.D., Jun Lin, M.D., Yuli Qian,

Endometriotic haptoglobin binds to peritoneal macrophages and alters their function in women with endometriosis Kathy L Sharpe-Timms, Ph.D., Randy L.

Interleukin 1β, interleukin-6, and tumor necrosis factor-α in endometriotic tissue and in endometrium Agneta Bergqvist, M.D., Ph.D., Christine Bruse,

Human sperm cells express CD44

Lipopolysaccharide-promoted proliferation of endometriotic stromal cells via induction of tumor necrosis factor α and interleukin-8 expression Yumiko.

Pharmacologic therapies in endometriosis: a systematic review

Effects of exogenous estrogen on uterine leukocyte recruitment

Nerve fibers and menstrual cycle in peritoneal endometriosis

Spontaneous and stimulated secretion of monocyte chemotactic protein-1 and macrophage migration inhibitory factor by peritoneal macrophages in women with.

Immunobiology of endometriosis

Steroid receptor and aromatase expression in baboon endometriotic lesions Asgerally T Fazleabas, Ph.D., Allison Brudney, B.S., Daniel Chai, D.V.M., David.

Clemens B. Tempfer, M. D. , M. B. A. , René Wenzl, M. D. , M. B. A

Altered expression of a cell-cycle suppressor gene, Tob-1, in endometriotic cells by cDNA array analyses Dan I Lebovic, M.D., Russell A Baldocchi, Ph.D.,

Presentation transcript:

Fertility and Sterility Epithelial neutrophil-activating peptide 78 concentrations are elevated in the peritoneal fluid of women with endometriosis Michael D Mueller, M.D., Luca Mazzucchelli, M.D., Caroline Buri, M.D., Dan I Lebovic, M.D., M.A., Ekkehard Dreher, M.D., Robert N Taylor, M.D., Ph.D. Fertility and Sterility Volume 79, Pages 815-820 (March 2003) DOI: 10.1016/S0015-0282(02)04828-8

FIGURE 1 Amplification of total RNA from endometriosis lesions for epithelial neutrophil-activating peptide 78. Two independent endometriotic lesions (lanes 1 and 2) expressed the expected 162–base pair product, whereas no bands were identified in the control lane (NT2-N cells) (lane 3). Peritoneal macrophages also clearly expressed the expected 162–base pair amplicon (lane 4). Mueller. ENA-78 in endometriosis. Fertil Steril 2003. Fertility and Sterility 2003 79, 815-820DOI: (10.1016/S0015-0282(02)04828-8)

FIGURE 2 (A) Concentrations of epithelial neutrophil-activating peptide 78 protein in endometriosis stromal cells before (Control) and after stimulation with interleukin (IL)-1β. Data are expressed as mean (±SE) from six independent cultures. (B) Concentrations of epithelial neutrophil-activating peptide 78 protein in peritoneal macrophages before (Control) and after stimulation with lipopolysaccharide (LPS). Data are expressed as mean (±SE) from five independent cultures. Mueller. ENA-78 in endometriosis. Fertil Steril 2003. Fertility and Sterility 2003 79, 815-820DOI: (10.1016/S0015-0282(02)04828-8)

FIGURE 3 Expression of epithelial neutrophil-activating peptide 78 (ENA-78) messenger RNA in endometriosis implants. (A) In situ hybridization of an endometriosis lesion with 35S-labeled RNA antisense probe specific for ENA-78 demonstrates that ectopic endometrial glandular cells express this chemokine. (B) No signal is visible in the negative control hybridized with a sense probe. (C) Scattered cells within the endometriotic stroma also express ENA-78 transcripts. (D) Colocalization with CD68 antibodies (magenta staining) indicate that some of these stromal cells are tissue macrophages, whereas the remaining mesenchymal cells appear to be of fibroblastic origin. Original magnification, ×200. Mueller. ENA-78 in endometriosis. Fertil Steril 2003. Fertility and Sterility 2003 79, 815-820DOI: (10.1016/S0015-0282(02)04828-8)