Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms Aaron M. Levy, MDa, Hirohito Kita, MDb, Sidney F. Phillips, MDa, Paul.

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Presentation transcript:

Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms Aaron M. Levy, MDa, Hirohito Kita, MDb, Sidney F. Phillips, MDa, Paul A. Schkade, MDc, Phillip D. Dyer, MDc, Gerald J. Gleich, MDb, Vincent A. Dubravec, MDc Journal of Allergy and Clinical Immunology Volume 101, Issue 5, Pages 613-620 (May 1998) DOI: 10.1016/S0091-6749(98)70168-X Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Peak peripheral blood eosinophil counts of responders (trial 1, numbers in circles and trial 2, numbers in squares) during daily shiitake mushroom powder ingestion (y-axis) in relation to average baseline eosinophil count (x-axis). Range in normal subjects (shaded gray) adapted from Rud.17 Peak eosinophil counts during two open-label trials are shown with subject's numerical designations. Note that all baseline eosinophil counts fell within normal range. Journal of Allergy and Clinical Immunology 1998 101, 613-620DOI: (10.1016/S0091-6749(98)70168-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 Patterns of responses to daily shiitake mushroom ingestion in first-time responder (subject 1) in trial 2 (filled diamonds) (A) and repeat responder (subject 10) in trial 1 (open diamonds) and trial 2 (filled diamonds) (B). Shiitake ingestion was from day 1 to day 70; arrows show last day of shiitake ingestion. No data available in B for day 154 neutrophils. Journal of Allergy and Clinical Immunology 1998 101, 613-620DOI: (10.1016/S0091-6749(98)70168-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 3 Comparison of peak-to-baseline ratios of bloodeosinophil counts, serum MBP, and stool EDN during daily shiitake mushroom ingestion. A, Peak-to-baseline ratios of blood eosinophil counts in responders and nonresponders. B, Peak-to-baseline ratios of serum MBP concentration in responders and nonresponders. C, Peak-to-baseline ratios of stool EDN concentration in responders and nonresponders. In all figures, median values for groups were compared by using Wilcoxon rank sum test. Journal of Allergy and Clinical Immunology 1998 101, 613-620DOI: (10.1016/S0091-6749(98)70168-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 3 Comparison of peak-to-baseline ratios of bloodeosinophil counts, serum MBP, and stool EDN during daily shiitake mushroom ingestion. A, Peak-to-baseline ratios of blood eosinophil counts in responders and nonresponders. B, Peak-to-baseline ratios of serum MBP concentration in responders and nonresponders. C, Peak-to-baseline ratios of stool EDN concentration in responders and nonresponders. In all figures, median values for groups were compared by using Wilcoxon rank sum test. Journal of Allergy and Clinical Immunology 1998 101, 613-620DOI: (10.1016/S0091-6749(98)70168-X) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 4 Blocking of eosinophil viability activity in serum by antibodies to cytokines. Serum from subject 6 in trial 1 was pretreated with anti-IL-5, anti-IL-3, and/or anti-GM-CSF antibody (5 μg/ml final concentration). Eosinophils from normal donor were incubated with pretreated serum. After 4 days at 37° C, eosinophil viability was determined as described in Methods section. Single samples were counted by using fluorescence-activated cell-sorting technology. Medium shows viability of eosinophils cultured without subject's serum. GM, anti-GM-CSF. Journal of Allergy and Clinical Immunology 1998 101, 613-620DOI: (10.1016/S0091-6749(98)70168-X) Copyright © 1998 Mosby, Inc. Terms and Conditions