Shinya Murakami, MD. , Emile A. Bacha, MD

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Presentation transcript:

Inhaled nitric oxide and pentoxifylline in rat lung transplantation from non-heart-beating donors Shinya Murakami, MD*, Emile A. Bacha, MD**, Philippe Hervé, MD, Hélène Détruit, Alain R. Chapelier, MD, Philippe G. Dartevelle, MD, Guy-Michel Mazmanian, MD The Journal of Thoracic and Cardiovascular Surgery Volume 113, Issue 5, Pages 821-829 (May 1997) DOI: 10.1016/S0022-5223(97)70254-X Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Experimental protocol. NO, Nitric oxide; PTX, pentoxifylline; PA, pulmonary artery; MPO, myeloperoxidase; W/D, wet/dry ratio. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 821-829DOI: (10.1016/S0022-5223(97)70254-X) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 2 Effect of nitric oxide (NO) on preservation solution flush time (time required to perfuse 25 ml at constant pressure). Data are shown as the mean ± standard error of the mean. *p < 0.05 versus control; †p < 0.05 versus pentoxifylline group (PTX). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 821-829DOI: (10.1016/S0022-5223(97)70254-X) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 3 Recipient actuarial survival. *p < 0.05 versus control group; †p < 0.05 versus pentoxifylline group (PTX); ‡p < 0.05 versus nitric oxide group (NO). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 821-829DOI: (10.1016/S0022-5223(97)70254-X) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 Pulmonary artery flow (PA flow) and pulmonary vascular resistance (PVR) 5 minutes after ligation of the native right pulmonary artery. Data are shown as the mean ± standard error of the mean. *p < 0.05 versus control group; †p < 0.05 versus pentoxifylline group (PTX); ‡p < 0.05 versus nitric oxide group (NO). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 821-829DOI: (10.1016/S0022-5223(97)70254-X) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 Pulmonary artery flow (PA flow) and pulmonary vascular resistance (PVR) 5 minutes after ligation of the native right pulmonary artery. Data are shown as the mean ± standard error of the mean. *p < 0.05 versus control group; †p < 0.05 versus pentoxifylline group (PTX); ‡p < 0.05 versus nitric oxide group (NO). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 821-829DOI: (10.1016/S0022-5223(97)70254-X) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 Pulmonary artery flow (PA flow) and pulmonary vascular resistance (PVR) of nitric oxide (NO) and nitric oxide + pentoxifylline (NO/PTX) groups at the final time at which the recipients were alive. Data are shown as the mean ± standard error of the mean. ‡p < 0.05 versus NO group. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 821-829DOI: (10.1016/S0022-5223(97)70254-X) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 Pulmonary artery flow (PA flow) and pulmonary vascular resistance (PVR) of nitric oxide (NO) and nitric oxide + pentoxifylline (NO/PTX) groups at the final time at which the recipients were alive. Data are shown as the mean ± standard error of the mean. ‡p < 0.05 versus NO group. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 821-829DOI: (10.1016/S0022-5223(97)70254-X) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 6 Grafted lung wet/dry weight ratio (W/D). Data are shown as the mean ± standard error of the mean. *p < 0.05 versus control group; †p < 0.05 versus pentoxifylline (PTX) group; ‡p < 0.05 versus NO group. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 821-829DOI: (10.1016/S0022-5223(97)70254-X) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 7 Grafted lung myeloperoxidase (MPO) activity. Because PMN sequestration is time-dependent, values were compared separately for control and pentoxifylline (PTX) groups (left panel) and nitric oxide (NO) and NO+PTX groups (right panel). Data are shown as the mean ± standard error of the mean. ‡p < 0.05 versus NO group. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 821-829DOI: (10.1016/S0022-5223(97)70254-X) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 7 Grafted lung myeloperoxidase (MPO) activity. Because PMN sequestration is time-dependent, values were compared separately for control and pentoxifylline (PTX) groups (left panel) and nitric oxide (NO) and NO+PTX groups (right panel). Data are shown as the mean ± standard error of the mean. ‡p < 0.05 versus NO group. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 821-829DOI: (10.1016/S0022-5223(97)70254-X) Copyright © 1997 Mosby, Inc. Terms and Conditions