A Behavioral Role for Dendritic Integration

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Presentation transcript:

A Behavioral Role for Dendritic Integration Matthew F. Nolan, Gael Malleret, Josh T. Dudman, Derek L. Buhl, Bina Santoro, Emma Gibbs, Svetlana Vronskaya, Gyorgy Buzsaki, Steven Siegelbaum, Eric R. Kandel, Alexei Morozov Cell Volume 120, Issue 1, Pages 151-152 (January 2005) DOI: 10.1016/j.cell.2004.12.032

Figure 6 Effects of HCN1 Knockout on Schaffer Collateral and Perforant Path EPSPs in CA1 Pyramidal Cells (A and B) Schematic illustration of the recording configuration and examples of somatically recorded EPSPs evoked by stimulation of Schaffer collateral inputs (A) and perforant path inputs (B). Subthreshold Schaffer collateral EPSPs from HCN1f/f mice (n = 8) and HCN1f/f,cre mice (n = 10) had 10%–90% rise times of 6.3 ± 0.9 ms and 6.7 ± 1.6 ms, respectively (p = 0.84), decay times of 38.6 ± 7.0 ms and 51.3 ± 4.8 ms (p = 0.14), and areas of 366.2 ± 55.9 mV.ms and 617.2 ± 74.6 mV.ms (p = 0.02). The mean amplitude for HCN1f/f and HCN1f/f,cre Schaffer collateral EPSPs respectively, was 10.6 ± 1.6 mV and 11.5 ± 1.7 mV (p = 0.7) with a stimulus of duration of 0.1 ms and intensity of 6 ± 0.8 V and 5.7 ± 0.5 V (p = 0.75). Subthreshold perforant path EPSPs from HCN1f/f mice (n = 8) and HCN1f/f,cre mice (n = 12) evoked by stimuli of amplitude 15 V and duration 0.1 ms had 10%–90% rise times of 7.14 ± 0.52 ms and 8.82 ± 0.80 ms, respectively (p = 0.14), halfwidths of 38.8 ± 6.4 ms and 57.6 ± 4.6 ms (p = 0.03). The mean amplitude for HCN1f/f and HCN1f/f,cre perforant path EPSPs, respectively, was 1.6 ± 0.4 mV and 2.4 ± 0.3 mV (p = 0.1) in response to stimuli with amplitude of 15 V and 1.7 ± 0.5 mV and 3.59 ± 0.6 mV (p = 0.04) in response to stimuli with amplitude of 25 V. (C) Plot of the relationship between stimulus strength and the slope of EPSPs in CA1 pyramidal cells, from HCN1f/f mice (n = 6) and HCN1f/f,cre mice (n = 8), evoked by stimulation of Schaffer collateral inputs. (D and E) Plot of the amplitude (D) and the area (E) as a function of stimulus strength for perforant path EPSPs recorded from CA1 pyramidal cells. (F and G) Plot of relationship between stimulus strength and the slope of field EPSPs recorded from stratum radiatum (F) (HCN1f/f, n = 10, HCN1f/f,cre, n = 16) or stratum lacunosum moleculare (G) (HCN1f/f, n = 8, HCN1f/f,cre, n = 11) in response to activation of Schaffer collateral or perforant path inputs, respectively. Cell 2005 120, 151-152DOI: (10.1016/j.cell.2004.12.032)