The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity

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Presentation transcript:

The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity Amit Nahum, MD, PhD, Harjit Dadi, PhD, Andrea Bates, BSc, Chaim M. Roifman, MD Journal of Allergy and Clinical Immunology Volume 127, Issue 2, Pages 528-531 (February 2011) DOI: 10.1016/j.jaci.2010.09.031 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, TLR3 expression on HEK-293 cells transfected with TLR3 WT (left) or TLR3 L412F (right), as measured by means of flow cytometric assay. B, NF-κB response element activation by Poly I:C in HEK293 cells transfected with the WT (shaded bar) or L412F variant (filled bar) TLR3. Results are expressed in luminescence counts per second (LCPS), representing transcription measurement of an alkaline phosphatase secreted to medium and an average of 4 different experiments. C, Average production of IFN-γ in PBMCs from 5 healthy control subjects (shaded bars) and 5 patients (filled bars). PBMCs were stimulated with Poly I:C for 24 hours, and supernatants were collected for ELISA. Cells were stained for TLR3 and measured to verify a comparable expression by means of flow cytometry. Journal of Allergy and Clinical Immunology 2011 127, 528-531DOI: (10.1016/j.jaci.2010.09.031) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions