Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers A.R. Absalom,

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Presentation transcript:

Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers A.R. Absalom, M. Lee, D.K. Menon, S.R. Sharar, T. De Smet, J. Halliday, M. Ogden, P. Corlett, G.D. Honey, P.C. Fletcher British Journal of Anaesthesia Volume 98, Issue 5, Pages 615-623 (April 2007) DOI: 10.1093/bja/aem063 Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 1 Measured ketamine concentrations (ng ml−1). Each filled circle represents one data point. Lines linking data points indicate which samples came from the same subject, and do not indicate estimated or extrapolated concentrations between samples. British Journal of Anaesthesia 2007 98, 615-623DOI: (10.1093/bja/aem063) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 2 Measured and predicted ketamine concentrations over time. Vertical bars represent the mean (sd) measured ketamine concentrations, but depicted at the average time (from the start of the infusions) at which the samples were obtained. Horizontal bars in the middle of the vertical bars represent the sd of the time interval at which the samples were obtained. British Journal of Anaesthesia 2007 98, 615-623DOI: (10.1093/bja/aem063) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 3 Trends in mean performance errors for each of the models during the different studies. British Journal of Anaesthesia 2007 98, 615-623DOI: (10.1093/bja/aem063) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions