Lysophosphatidylcholine induces platelet-derived growth factor gene expression in a human mesangial cell line Yoshinori Tone, Susumu Yukawa, Zac Varghese,

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Lysophosphatidylcholine induces platelet-derived growth factor gene expression in a human mesangial cell line Yoshinori Tone, Susumu Yukawa, Zac Varghese, John F. Moorhead Kidney International Volume 56, Pages S182-S185 (July 1999) DOI: 10.1046/j.1523-1755.1999.07147.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 The potential of phosphatidylcholine (PC) and lysophosphatidylcholine (lysoPC) to induce [3H] thymidine incorporation. LysoPC treatment up-regulated the [3H] thymidine incorporation level in (A) a dose- and (B) time-dependent fashion in human glomerular mesangial cell line (HMCL). PC treatment did not increase [3H] thymidine incorporation (A, B). The control values were at 0 μ M of PC or lysoPC. Data express mean ± SE. Kidney International 1999 56, S182-S185DOI: (10.1046/j.1523-1755.1999.07147.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 The potential of phosphatidylcholine (PC) and lysophosphatidylcholine (lysoPC) to induce platelet-derived growth factor (PDGF) gene expression. PC treatment did not induce the mRNA expression of either PDGF A or B chains in human glomerular mesangial cell line (HMCL). LysoPC did not induce PDGF A chain mRNA expression but did induce B chain mRNA expression. The control values were at 0 μ M of PC or lysoPC. These data are representative of three replicate experiments. Kidney International 1999 56, S182-S185DOI: (10.1046/j.1523-1755.1999.07147.x) Copyright © 1999 International Society of Nephrology Terms and Conditions