Supplemental Figure 4 A no agonist MALP2 PAM3CSK4 GFP WT F217S

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Supplemental Figure 4 A no agonist MALP2 PAM3CSK4 GFP WT F217S GFP WT F217S GFP WT F217S p-IRAK1 (T209) IRAK1 B GFP WT F217S C GFP GFP WT WT F217S F217S Figure S4. TLR2-F217 and downstream signals. (a) Western blot characterization of IRAK1 phospho-T209 in 293T cells transfected with either WT or F217S TLR2 and treated with no agonist, MALP2 or PAM3CSK4. Top, Western blot analysis of p-T209 of IRAK1; Bottom, Western blot analysis of IRAK1. (b) Q-PCR analysis of IL8-RB gene expression in 293T with indicated transfection and agonist treatments. (b) Q-PCR analysis of IL8 and JMJD3 gene expression in OCI-AML3 cells with indicated transfection and agonist treatments.