Leptin signaling and body weight are independent mediators of spontaneous knee osteoarthritis in female rats J. Hudson, M. West, Y. Fu, T. Griffin Osteoarthritis.

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Presentation transcript:

Leptin signaling and body weight are independent mediators of spontaneous knee osteoarthritis in female rats J. Hudson, M. West, Y. Fu, T. Griffin Osteoarthritis and Cartilage Volume 21, Pages S53-S54 (April 2013) DOI: 10.1016/j.joca.2013.02.124 Copyright © 2013 Terms and Conditions

Figure 1 Knee OA scores in leptin receptor mutant Zucker fatty rats (A) and F344BN rats undergoing chronic systemic leptin treatment (B). Obesity in the absence of leptin signaling and increased systemic leptin in the absence of obesity were both sufficient to induce site-specific increases in spontaneous knee OA (∗p<0.05). Osteoarthritis and Cartilage 2013 21, S53-S54DOI: (10.1016/j.joca.2013.02.124) Copyright © 2013 Terms and Conditions