Real-time breath monitoring of propofol and its volatile metabolites during surgery using a novel mass spectrometric technique: a feasibility study G.R.

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Real-time breath monitoring of propofol and its volatile metabolites during surgery using a novel mass spectrometric technique: a feasibility study G.R. Harrison, A.D.J. Critchley, C.A. Mayhew, J.M. Thompson British Journal of Anaesthesia Volume 91, Issue 6, Pages 797-799 (December 2003) DOI: 10.1093/bja/aeg271 Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 1 Mass spectrum of the air sampled over serum taken from a patient anaesthetized with propofol. This spectrum represents the average of 10 scans with the background subtracted. The peaks, which can be uniquely defined to propofol, are identified. The other mass peaks at 97, 101, 107, 111, 113, 115, 135, 139, and 141 amu remain unassigned. British Journal of Anaesthesia 2003 91, 797-799DOI: (10.1093/bja/aeg271) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 2 Real-time propofol and metabolite concentration measurements for the first 10 min of expired breath sampling from a patient undergoing surgery. This patient showed an initial surge of propofol shortly after the operation started, corresponding to approximately 50 p.p.b. by volume levels and then steadily decreasing to a value of about 5 p.p.b. by volume within about 10 min of the operation. British Journal of Anaesthesia 2003 91, 797-799DOI: (10.1093/bja/aeg271) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions