Mark R. Johnson, Thomas W. Ferkol, Ross W. Shepherd

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Presentation transcript:

Energy cost of activity and exercise in children and adolescents with cystic fibrosis Mark R. Johnson, Thomas W. Ferkol, Ross W. Shepherd Journal of Cystic Fibrosis Volume 5, Issue 1, Pages 53-58 (January 2006) DOI: 10.1016/j.jcf.2005.10.001 Copyright © 2005 European Cystic Fibrosis Society Terms and Conditions

Fig. 1 Measured energy expenditure in cystic fibrosis adolescents. The mean REE (white columns) was similar between healthy CF and non-CF adolescents (1393 calories/day and 1290 calories/day, respectively; p=0.17). In contrast, the mean ECA (gray columns) in CF adolescents was significantly lower compared to non-CF subjects (267 calories/day and 769 calories/day, respectively; p=0.02). Journal of Cystic Fibrosis 2006 5, 53-58DOI: (10.1016/j.jcf.2005.10.001) Copyright © 2005 European Cystic Fibrosis Society Terms and Conditions

Fig. 2 Measured energy expenditure in cystic fibrosis adolescents following dietary and exercise interventions. CF patients began a monitored, six-week exercise program after they were randomized to either carbohydrate or lipid supplementation groups. Both REE (white columns) and ECA (gray columns) were measured before and after interventions. There were no significant changes in EE after intervention with exercise and either dietary regimen. Journal of Cystic Fibrosis 2006 5, 53-58DOI: (10.1016/j.jcf.2005.10.001) Copyright © 2005 European Cystic Fibrosis Society Terms and Conditions

Fig. 3 Exercise characteristics of persons with cystic fibrosis. The exercise characteristics of CF adolescents were measured as described in Methods. (a) The expiratory oxygen uptake (VO2) was similar between CF adolescents () and non-CF subjects (); while (b) carbon dioxide excretion (VCO2); (c) respiratory quotient (RQ); and (d) ventilatory equivalent for oxygen (VeO2) were consistently higher in CF adolescents, which suggested that CF individuals hyperventilate during exercise as compared to controls to obtain a similar VO2. (e) End tidal oxygen (ETO2) is higher, and (f) end tidal carbon dioxide (ETCO2,) is lower in those with CF indicating that hyperventilation observed in this healthy CF population with normal lung function was not a result of V/Q mismatching. Journal of Cystic Fibrosis 2006 5, 53-58DOI: (10.1016/j.jcf.2005.10.001) Copyright © 2005 European Cystic Fibrosis Society Terms and Conditions