Pharmacokinetic characteristics and microbiologic appropriateness of cefazolin for perioperative antibiotic prophylaxis in elective cardiac surgery Christian.

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Presentation transcript:

Pharmacokinetic characteristics and microbiologic appropriateness of cefazolin for perioperative antibiotic prophylaxis in elective cardiac surgery Christian Lanckohr, MD, Dagmar Horn, Swantje Voeller, PhD, Georg Hempel, PhD, Manfred Fobker, PhD, Henryk Welp, MD, Robin Koeck, MD, Bjoern Ellger, MD The Journal of Thoracic and Cardiovascular Surgery Volume 152, Issue 2, Pages 603-610 (August 2016) DOI: 10.1016/j.jtcvs.2016.04.024 Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A, Administration of cefazolin and blood sampling during the perioperative period. Cefazolin was administered during the induction of anesthesia and shortly after the institution of cardiopulmonary bypass. Blood samples were taken at 7 time points. B, Serum concentrations of cefazolin obtained at different time points. Red bars denote median values. Intervals between sampling points on the x-axis are not uniform. The period of cardiopulmonary bypass is marked. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 603-610DOI: (10.1016/j.jtcvs.2016.04.024) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Performance of a 1-compartment pharmacokinetic model. Each circle represents a cefazolin concentration. The y-axis denotes the observed (ie, measured) drug levels, the x-axis reflects the predicted (ie, calculated) levels. A, Observed versus individually predicted drug levels. B, Observed versus population predictions. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 603-610DOI: (10.1016/j.jtcvs.2016.04.024) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Volumes of distribution of cefazolin calculated on the basis of measured cefazolin levels. Each dot represents an individual patient, the red bar denotes the median values. The volumes of distribution are shown for the periods before, during and after cardiopulmonary bypass (CPB). The Journal of Thoracic and Cardiovascular Surgery 2016 152, 603-610DOI: (10.1016/j.jtcvs.2016.04.024) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Performance of a pharmacokinetic model in predicting cefazolin levels. The Journal of Thoracic and Cardiovascular Surgery 2016 152, 603-610DOI: (10.1016/j.jtcvs.2016.04.024) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions