Proliferation of smooth muscle cells in acute allograft vascular rejection Jun Amano, MDa, Shigeru Ishiyama, MDb, Toshiro Nishikawa, MDb, Hiroyuki Tanaka,

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Presentation transcript:

Proliferation of smooth muscle cells in acute allograft vascular rejection Jun Amano, MDa, Shigeru Ishiyama, MDb, Toshiro Nishikawa, MDb, Hiroyuki Tanaka, MDc, Ryozo Nagai, MDd, Fumiaki Marumo, MDe, Michiaki Hiroe, MDe The Journal of Thoracic and Cardiovascular Surgery Volume 113, Issue 1, Pages 19-25 (January 1997) DOI: 10.1016/S0022-5223(97)70395-7 Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Expression of MHC isoforms and bromodeoxyuridine (BrdU) in allografted aorta at 10 days after transplantation. Serial sections of ascending aorta of transplanted heart display severe intimal thickening. SM1-positive SMCs are negative for SM2, but positive for SMemb. HE, Hematoxylin-eosin stain; EV, van Gieson elastin stain (original magnification ×400). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 19-25DOI: (10.1016/S0022-5223(97)70395-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Expression of MHC isoforms and bromodeoxyuridine (BrdU) in allografted aorta at 10 days after transplantation. Serial sections of ascending aorta of transplanted heart display severe intimal thickening. SM1-positive SMCs are negative for SM2, but positive for SMemb. HE, Hematoxylin-eosin stain; EV, van Gieson elastin stain (original magnification ×400). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 19-25DOI: (10.1016/S0022-5223(97)70395-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Expression of MHC isoforms and bromodeoxyuridine (BrdU) in allografted aorta at 10 days after transplantation. Serial sections of ascending aorta of transplanted heart display severe intimal thickening. SM1-positive SMCs are negative for SM2, but positive for SMemb. HE, Hematoxylin-eosin stain; EV, van Gieson elastin stain (original magnification ×400). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 19-25DOI: (10.1016/S0022-5223(97)70395-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Expression of MHC isoforms and bromodeoxyuridine (BrdU) in allografted aorta at 10 days after transplantation. Serial sections of ascending aorta of transplanted heart display severe intimal thickening. SM1-positive SMCs are negative for SM2, but positive for SMemb. HE, Hematoxylin-eosin stain; EV, van Gieson elastin stain (original magnification ×400). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 19-25DOI: (10.1016/S0022-5223(97)70395-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Expression of MHC isoforms and bromodeoxyuridine (BrdU) in allografted aorta at 10 days after transplantation. Serial sections of ascending aorta of transplanted heart display severe intimal thickening. SM1-positive SMCs are negative for SM2, but positive for SMemb. HE, Hematoxylin-eosin stain; EV, van Gieson elastin stain (original magnification ×400). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 19-25DOI: (10.1016/S0022-5223(97)70395-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Expression of MHC isoforms and bromodeoxyuridine (BrdU) in allografted aorta at 10 days after transplantation. Serial sections of ascending aorta of transplanted heart display severe intimal thickening. SM1-positive SMCs are negative for SM2, but positive for SMemb. HE, Hematoxylin-eosin stain; EV, van Gieson elastin stain (original magnification ×400). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 19-25DOI: (10.1016/S0022-5223(97)70395-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 2 Expression of bromodeoxyuridine in allografted aorta, epicardial large coronary arteries (large CA), and intramyocardial small coronary arteries (small CA) at 2, 5, 7, and 10 days after transplantation. *p < 0.05 compared with aorta; †p < 0.05 compared with large coronary arteries. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 19-25DOI: (10.1016/S0022-5223(97)70395-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 3 Expression of SMemb in allografted aorta, epicardial large coronary arteries (large CA), and intramyocardial small coronary arteries (small CA) at 2, 5, 7, and 10 days after transplantation. *p < 0.05 compared with aorta; †p < 0.05 compared with large coronary arteries. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 19-25DOI: (10.1016/S0022-5223(97)70395-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 Sections of aorta and coronary arteries in allografted heart at 10 days after transplantation stained with hematoxylin-eosin stain. A, Longitudinal section of aorta and ostium of left coronary artery (LCA) (original magnification ×40); B, cross-section of proximal left anterior descending coronary artery (original magnification ×100); C, cross-section of intramyocardial small coronary artery (original magnification ×400); D, cross-section of arteriole (original magnification ×400). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 19-25DOI: (10.1016/S0022-5223(97)70395-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 Sections of aorta and coronary arteries in allografted heart at 10 days after transplantation stained with hematoxylin-eosin stain. A, Longitudinal section of aorta and ostium of left coronary artery (LCA) (original magnification ×40); B, cross-section of proximal left anterior descending coronary artery (original magnification ×100); C, cross-section of intramyocardial small coronary artery (original magnification ×400); D, cross-section of arteriole (original magnification ×400). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 19-25DOI: (10.1016/S0022-5223(97)70395-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 Sections of aorta and coronary arteries in allografted heart at 10 days after transplantation stained with hematoxylin-eosin stain. A, Longitudinal section of aorta and ostium of left coronary artery (LCA) (original magnification ×40); B, cross-section of proximal left anterior descending coronary artery (original magnification ×100); C, cross-section of intramyocardial small coronary artery (original magnification ×400); D, cross-section of arteriole (original magnification ×400). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 19-25DOI: (10.1016/S0022-5223(97)70395-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 Sections of aorta and coronary arteries in allografted heart at 10 days after transplantation stained with hematoxylin-eosin stain. A, Longitudinal section of aorta and ostium of left coronary artery (LCA) (original magnification ×40); B, cross-section of proximal left anterior descending coronary artery (original magnification ×100); C, cross-section of intramyocardial small coronary artery (original magnification ×400); D, cross-section of arteriole (original magnification ×400). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 19-25DOI: (10.1016/S0022-5223(97)70395-7) Copyright © 1997 Mosby, Inc. Terms and Conditions