Volume 165, Issue 2, Pages (April 2016)

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Volume 165, Issue 2, Pages 267-269 (April 2016) CSR-1 Slices a Balance Ruby Yu, Danesh Moazed Cell Volume 165, Issue 2, Pages 267-269 (April 2016) DOI: 10.1016/j.cell.2016.03.019 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 CSR-1 Slicing and 22G RNA Levels Fine-Tune Maternal mRNA Levels in Oocytes CSR-1 mediates slicer-dependent downregulation of transcripts with complementarity to antisense 22G RNAs in a dose-dependent manner, likely in the cytoplasm. This regulation fine-tunes the levels of various maternal mRNAs that are deposited into oocytes and is critical for central processes such as chromosome segregation. Additionally, previous studies have shown that CSR-1 also transcriptionally activates a subset of genes, protecting them from piRNA-initiated epigenetic silencing (mediated by HRDE-1/WAGO-9 Argonaute) in the germline. Cell 2016 165, 267-269DOI: (10.1016/j.cell.2016.03.019) Copyright © 2016 Elsevier Inc. Terms and Conditions