Volume 16, Issue 3, Pages 217-218 (March 2015) Confetti Clarifies Controversy: Neural Crest Stem Cells Are Multipotent  Marianne Bronner  Cell Stem Cell  Volume 16, Issue 3, Pages 217-218 (March 2015) DOI: 10.1016/j.stem.2015.02.016 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Diagram Illustrating Two Possible Scenarios to Explain the Ability of Premigratory Neural Crest Cells to Contribute to Diverse Cell Types and Structures Left: Individual premigratory neural crest cells within the dorsal neural tube (NT) may be multipotent, with the ability to contribute to numerous different cell types in diverse locations. These include neurons (blue) and glia (green) of the dorsal root ganglia (DRG) and sympathetic ganglia (SG); Schwann cells (yellow) of the ventral root (VR); and melanocytes (red) along the dorsolateral pathway (DLP). The multipotent cells migrate to diverse sites and differentiate into appropriate cell types in response to local environmental cues. Right: Alternatively, unipotent premigratory neural crest cells may be a mixture of restricted precursors, each destined to form a single cell type. They then migrate to appropriate sites and differentiate according to their predetermined fates (drawing by Paige O’Connell). Cell Stem Cell 2015 16, 217-218DOI: (10.1016/j.stem.2015.02.016) Copyright © 2015 Elsevier Inc. Terms and Conditions