Identification of DPB1 Permissive Unrelated Donors Is Highly Likely Kevin Tram, Gretta Stritesky, Kim Wadsworth, Jennifer Ng, Claudio Anasetti, Jason Dehn  Biology of Blood and Marrow Transplantation  Volume 23, Issue 1, Pages 81-86 (January 2017) DOI: 10.1016/j.bbmt.2016.10.021 Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Study enrollment and testing schema. Displays the protocol for patient enrollment criteria and donor selection cascade. Patients were evaluated for existing DPB1 permissive-matched donors, with selection prioritization for young donors, male, and those with available stored samples for testing. Patients were allowed a total of 10 donors tested, with TCE groups 1 and 2 allowed an additional 5 donors tested. Patient enrollment per group shown in [n]. Biology of Blood and Marrow Transplantation 2017 23, 81-86DOI: (10.1016/j.bbmt.2016.10.021) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 DPB1 permissive match status based on patient search productivity. Displays the number of potential 10/10 HLA–matched donors with a HapLogic allele-matching prediction >75% (ie, based on haplotype frequencies and HLA typing the donor is at least 75% likely to be allele matched at HLA-A, -B, -C, -DRB1, -DQB1) separated by those cases where a DPB1 permissive-match was identified. The majority of cases where no DPB1 permissive-match was found contained limited total number of potential donors. Plotted points are “jittered” to show density. Biology of Blood and Marrow Transplantation 2017 23, 81-86DOI: (10.1016/j.bbmt.2016.10.021) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions