Decreased Neutrophil Skin Infiltration After UVB Exposure in Patients with Polymorphous Light Eruption Ines J. Schornagel, Vigfús Sigurdsson, Evert H.J.

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Decreased Neutrophil Skin Infiltration After UVB Exposure in Patients with Polymorphous Light Eruption Ines J. Schornagel, Vigfús Sigurdsson, Evert H.J. Nijhuis, Carla A.F.M. Bruijnzeel-Koomen, Edward F. Knol Journal of Investigative Dermatology Volume 123, Issue 1, Pages 202-206 (July 2004) DOI: 10.1111/j.0022-202X.2004.22734.x Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Neutrophil elastase staining in the dermis of a healthy control and PLE patient after three MED UVB. (A+E) Unexposed (-UV), (B–D+F–H) hours after UVB exposure (+UV 3, 6, 18 h). UVB dose given in these volunteers was equal. Scale bar: 50 μm. Journal of Investigative Dermatology 2004 123, 202-206DOI: (10.1111/j.0022-202X.2004.22734.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Number of elastase positive neutrophils in the dermis in time after three MED UVB. () Controls (n=6), () PLE patients (n=5). Mean number of cells mm2±SEM, statistical significance *p<0.05, at t=18 h, between control group and PLE group. Journal of Investigative Dermatology 2004 123, 202-206DOI: (10.1111/j.0022-202X.2004.22734.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Chemotactic response of neutrophils towards IL-8 and C5a (A,B). () Controls (n=6), () PLE patients (n=5). Migratory index (μm cell), ±SEM, calculated for triplicate samples. Journal of Investigative Dermatology 2004 123, 202-206DOI: (10.1111/j.0022-202X.2004.22734.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Cell surface markers on human neutrophils. (▪) Controls (n=6), (□) PLE patients (n=5). Data are expressed in corrected mean fluorescence intensity (MFI), calculated by subtracting MFI for isotype controls. Data are based on geometric mean±SEM. Journal of Investigative Dermatology 2004 123, 202-206DOI: (10.1111/j.0022-202X.2004.22734.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 5 Increase in endothelial cells (EC) expressing ICAM-1 (A), and E-selectin (B) after three MED UVB irradiation. () Controls (n=6), () PLE patients (n=5). Increase is calculated as change compared with number of adhesion molecule expressing EC at t=0 h. Data are displayed as mean±SEM. Journal of Investigative Dermatology 2004 123, 202-206DOI: (10.1111/j.0022-202X.2004.22734.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions