Acute renal failure: From renal physiology to the renal transcriptome

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Acute renal failure: From renal physiology to the renal transcriptome Robert L. Safirstein Kidney International Volume 66, Pages S62-S66 (October 2004) DOI: 10.1111/j.1523-1755.2004.09110.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Maximum concentrating ability in control and cisplatin (CDDP)-treated animals following a 24-hour period of water depreviation and 1000 mU of ADH. Kidney International 2004 66, S62-S66DOI: (10.1111/j.1523-1755.2004.09110.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Radiohistogram of outer stripe of outer medulla of rat kidney taken from animal 5 days after cisplatin 5mg/kg BW. Note three cell fates: necrosis (ND) of cells lining injured S3 segment; apparent indifference of thick ascending limb (TAL) and collecting duct (CD) epithelial cells; cells of the proximal tubule (PT) undergoing DNA synthesis (arrow). Condensed nuclear debris may also be seen in such section indicating apoptotic bodies (not shown). Kidney International 2004 66, S62-S66DOI: (10.1111/j.1523-1755.2004.09110.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 3 Northern analysis of kidney c-fos and c-jun mRNA in control and cisplatin-induced acute renal failure. Kidney International 2004 66, S62-S66DOI: (10.1111/j.1523-1755.2004.09110.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 4 Heat map of the changes in mouse kidney gene expression after cisplatin injection. Using changes in gene expression of 3-fold or greater and applying hierarchic clustering, the expression profile of each of these genes that correlated with the expression profile of preproEGF by 0.99 or greater, and ordered by z-score. Kidney International 2004 66, S62-S66DOI: (10.1111/j.1523-1755.2004.09110.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 5 Predicted impact of cisplatin on renal metabolism of glucose and intracellular pH. Kidney International 2004 66, S62-S66DOI: (10.1111/j.1523-1755.2004.09110.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 6 Survival factors may influence the signal transduction and transcriptional programs initiated by stress. The balance between the prosurvival or prodeath aspects of the stress response determines the ultimate fate of the cells. Both the cyclin-kinase inhibitor p21 protein and extracellular-regulated kinase (ERK) protect renal cells from oxidant injury. Kidney International 2004 66, S62-S66DOI: (10.1111/j.1523-1755.2004.09110.x) Copyright © 2004 International Society of Nephrology Terms and Conditions