C-MET/Phospho-MET Protein Expression and MET Gene Copy Number in Non-small Cell Lung Carcinomas Koji Tsuta, MD, PhD, Yoshiki Kozu, MD, PhD, Takahiro.

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c-MET/Phospho-MET Protein Expression and MET Gene Copy Number in Non-small Cell Lung Carcinomas Koji Tsuta, MD, PhD, Yoshiki Kozu, MD, PhD, Takahiro Mimae, MD, Akihiko Yoshida, MD, Takashi Kohno, PhD, Ikuo Sekine, MD, PhD, Tomohide Tamura, MD, PhD, Hisao Asamura, MD, PhD, Koh Furuta, MD, PhD, Hitoshi Tsuda, MD, PhD Journal of Thoracic Oncology Volume 7, Issue 2, Pages 331-339 (February 2012) DOI: 10.1097/JTO.0b013e318241655f Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Representative images of a c-MET- and phospho-MET-positive case of adenocarcinoma. A, Positive staining of c-MET with brown-stained membranes and cytoplasm (original magnification, ×200). B, Positive staining of phospho-MET with brown-stained membranes (original magnification, ×200). Journal of Thoracic Oncology 2012 7, 331-339DOI: (10.1097/JTO.0b013e318241655f) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Representative image of a bright-field in situ hybridization (BISH)-positive case of sarcomatoid carcinoma. Amplified MET gene signals appear as clusters of black dots and two to four CEN7 signals as red dots in the nuclei (original magnification, ×400). Journal of Thoracic Oncology 2012 7, 331-339DOI: (10.1097/JTO.0b013e318241655f) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Overall survival (OS) analysis. A, OS curves for patients with c-MET-negative (solid line) and c-MET-positive (dashed line) non-small cell lung carcinomas (NSCLCs) (p=0.189). B, OS curves for patients with c-MET-negative (solid line) and c-MET-positive (dashed line) nonsquamous NSCLCs (p=0.684). C, OS curves for patients with phospho-MET-negative (solid line) and phospho-MET-positive (dashed line) NSCLCs (p=0.547). D, OS curves for patients with phospho-MET-negative (solid line) and phospho-MET-positive (dashed line) nonsquamous NSCLCs (p=0.825). E, OS curves for patients with MET BISH-negative (solid line) and MET BISH-positive (dashed line) NSCLCs (p=0.135). F, OS curves for patients with MET BISH-negative (solid line) and MET BISH-positive (dashed line) nonsquamous NSCLCs (p=0.019). Journal of Thoracic Oncology 2012 7, 331-339DOI: (10.1097/JTO.0b013e318241655f) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions