Biodistribution of the muNR-LU-10 and huNR-LU-13 antibodies in athymic nude mice bearing the s.c. Biodistribution of the muNR-LU-10 and huNR-LU-13 antibodies.

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Biodistribution of the muNR-LU-10 and huNR-LU-13 antibodies in athymic nude mice bearing the s.c. Biodistribution of the muNR-LU-10 and huNR-LU-13 antibodies in athymic nude mice bearing the s.c. SW1222 human tumor xenograft. Equimolar quantities of 131I-muNR-LU-10 and 125I-NR-LU-13 antibody were i.v. coinjected, and animals were sacrificed at 4, 24, 48, and 192 h after injection. A, biodistribution represented as the percentage of injected dose/gram of tissue. BL, blood; TA, tail; SK, skin; MU, muscle; BO, bone; LU, lung; LV, liver; SP, spleen; ST, stomach; KD, kidney; INT, intestine; TU, tumor. Bars, SD. B,131I-muNR-LU-10 and 125I-huNR-LU-13 tumor:blood ratio analyzed through 192 h after injection. Bars, SD. Scott S. Graves et al. Clin Cancer Res 1999;5:899-908 ©1999 by American Association for Cancer Research