Effects of E2 on levels of phospho-CREB in the DH of OVX females, sham males, and GDX males. Effects of E2 on levels of phospho-CREB in the DH of OVX females,

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Effects of E2 on levels of phospho-CREB in the DH of OVX females, sham males, and GDX males. Effects of E2 on levels of phospho-CREB in the DH of OVX females, sham males, and GDX males. A, DH infusion of E2 significantly increased levels of phospho-CREB in the DH of OVX females and sham males relative to same-sex vehicle-infused mice (*p < 0.05). B, In GDX males, E2 significantly increased phospho-CREB levels in the DH (*p < 0.05), and administration of U0126 did not block this increase. In sham males, there was a trend for E2 to increase phospho-CREB levels in the DH regardless of U0126 infusion (&p = 0.079). Representative blots for each antibody are shown to below the quantified data. Each bar represents the mean +/− SEM. Wendy A. Koss et al. eNeuro 2018;5:ENEURO.0267-18.2018 ©2018 by Society for Neuroscience