Association of Barrett's Esophagus With Type II Diabetes Mellitus: Results From a Large Population-based Case-Control Study  Prasad G. Iyer, Bijan J. Borah, Herbert C. Heien, Ananya Das, Gregory S. Cooper, Amitabh Chak  Clinical Gastroenterology and Hepatology  Volume 11, Issue 9, Pages 1108-1114.e5 (September 2013) DOI: 10.1016/j.cgh.2013.03.024 Copyright © 2013 AGA Institute Terms and Conditions

Figure 1 Marginal effects analysis for multivariable model of association of BE with DM2. The plot depicts the expected odds (risks) of developing BE for patients with or without the following baseline conditions for different BMI categories: GERD, DM2, and whether smoked. The 4 lines at the bottom of the graph, indicating small positive risk of BE for all weight categories, correspond to the groups of patients without GERD but with or without smoking and DM2 in the baseline. The 4 lines at the top of the graph pertain to the groups of patients with GERD in the baseline. Clearly, having GERD in the baseline is associated significantly with the development of BE, even after accounting for DM2 and smoking status in the baseline. The graph also suggests that for subjects with DM2 in the baseline, increasing BMI appears to be protective because the expected odds decline monotonically from normal BMI patients to morbidly obese patients. Clinical Gastroenterology and Hepatology 2013 11, 1108-1114.e5DOI: (10.1016/j.cgh.2013.03.024) Copyright © 2013 AGA Institute Terms and Conditions

Supplementary Figure 1 The plot depicts the expected odds (risks) of developing BE (defined as at least 2 diagnostic codes for BE and at least 1 endoscopy code) for patients with or without the following baseline conditions for different BMI categories: GERD, DM2, and whether smoked. The 4 lines at the bottom of the graph, indicating a small positive risk of BE for all weight categories, correspond to the groups of patients without GERD but with or without smoking and DM2 in the baseline. The 4 lines at the top of the graph pertain to the groups of patients with GERD in the baseline. Clearly, having GERD in the baseline is associated significantly with the development of BE, even after accounting for DM2 and smoking status in the baseline. The graph also suggests that for subjects with DM2 in the baseline, increasing BMI appears to be protective because the expected odds decrease monotonically from normal BMI patients to morbidly obese patients. Clinical Gastroenterology and Hepatology 2013 11, 1108-1114.e5DOI: (10.1016/j.cgh.2013.03.024) Copyright © 2013 AGA Institute Terms and Conditions

Supplementary Figure 2 The plot depicts the expected odds (risks) of developing BE (defined as the presence of at least 2 diagnostic codes for BE after the index date) for patients with or without the following baseline conditions for different BMI categories: GERD, DM2, and whether smoked. The 4 lines at the bottom of the graph, indicating a small positive risk of BE for all weight categories, correspond to the groups of patients without GERD but with or without smoking and DM2 in the baseline. The 4 lines at the top of the graph pertain to the groups of patients with GERD in the baseline. Clearly, having GERD in the baseline is associated significantly with the development of BE, even after accounting for DM2 and smoking status in the baseline. The graph also suggests that for subjects with DM2 in the baseline, increasing BMI appears to be protective because the expected odds decrease monotonically from normal BMI patients to morbidly obese patients. Clinical Gastroenterology and Hepatology 2013 11, 1108-1114.e5DOI: (10.1016/j.cgh.2013.03.024) Copyright © 2013 AGA Institute Terms and Conditions