Bioinformatics Necessary evil, panacea, or just a useful tool?

Slides:

Advertisements

Similar presentations

The pandemic and a brief ABC of influenza Thomas Abraham JMSC 6090.

Advertisements

Dr S Aboobakar Regional Public Health Superintendent.

F INDINGS National Institutes of Health National Institute of General Medical Sciences Viral Voyages Structural Biologist Mavis Agbandje-McKenna: Understanding.

The pandemic and a brief ABC of influenza Thomas Abraham JMSC 6090.

Treatment Recommendations of swine flu By Nesrien Mohammed Shalabi Ass. Prof of Thoracic Medicine 5/5/2009.

Department of Molecular Virology and Microbiology Swine ‘09 The 2009 H1N1 Influenza Pandemic.

Avian Flu Yurij Kobasa & Ambrish Patel. Overview 1. Background Information 2. Brief overview of genome structure 3. Origin/History 4. Geographical Distribution.

Avian influenza A simple introduction.

80% Influenza A — H3N2 (some H1N1) 20 % influenza B (orthomyoxiviridae – seals and humans only) Deaths above epidemic threshold – 50% hospitalizations.

Seasonal Influenza and Swine-Origin Influenza A (H1N1) Virus

Influenza Ieuan Davies. Signs and Symptoms Influenza is an acute, viral respiratory infection. Fever, chills, headache, aches and pains throughout the.

H1N1: “Swine Flu”. Why you should care… Every year between 5 and 20% of the population gets the flu. The CDC estimates that the flu kills 36,000 people.

OSELTAMIVIR (AKA TAMIFLU). WHAT IS IT? Tamiflu is a drug used to treat the flu (influenza A and B, as well as swine influenza A). Chemical formula C 16.

A PANDEMIC FLU SWINE FLU.

Bird Flu A threat to Insurance? Henk van Broekhoven.

How serious is the threat of an Avian flu Human Pandemic Avian (Bird) December 2005.

Developing a vaccine and how a pandemic could occur.

Influenza. The Blame Game The greatly feared pandemic flu virus has finally broken out. Millions are sick and thousands have already died. It is almost.

Pandemic Influenza; A Harbinger of Things to Come Michael T Osterholm PhD, MPH Director, Center for Infectious Disease Research and Policy Associate Director,

Emerging Viruses BY PLAN A. Topic Questions  Why are these new viruses more harmful compared to the previous form of the virus?  Why is it so difficult.

Microbiology of Influenza

Influenza What is it?. Influenza Virus Understanding Terminology Epidemic: serious outbreak in a single community, population or region Pandemic: epidemic.

The Flu Rapid Reading Exercise. The Flu Every year, 10 percent to 20 percent of Americans get sick with the flu (influenza). For most people, the fever,

April 25, 2009 Mexico Shuts Some Schools Amid Deadly Flu Outbreak Mexico’s flu season is usually over by now, but health officials have noticed a significant.

Avian Influenza "bird flu" Contagious disease of animals caused by viruses that normally infect only birds and pigs H5N1 can infect people (very rarely)

FLU. Orthomyxoviridae Eight segmented pieces of RNA, a structure that permits the introduction of new RNA. This is called genetic reassortment. This.

How does a virus that originally infected animals change in such a way that it can infect humans? Topic: Topic: H1N1 (Swine Flu) Rationale:  H1N1 or swine.

Swine Influenza (2009) Influenza A (H1N1) Lecture presented by Dr Ghassan Awar 02 May 2009.

Swine Flu Presenter: Ali Azarashk. Overview Introduction Classification History Transmission Signs and Symptoms Treatment.

HOW DO VIRUSES CROSS THE SPECIES BARRIER? Rachel Rezabek.

Facts about Influenza Viruses There are three types of influenza viruses: A, B, C A is most serious and it can genetically change rapidly and is the one.

Avian Influenza H5N1 Prepared by: Samia ALhabardi.

Influenza Influenza Virus magnified 100,000X. What is Influenza? Virus; causes chills, fever, sore throat, fatigue.

Dr A.J.France. Ninewells Hospital © A.J.France 2010.

Virion Structure and Organization

It’s Just Not the Flu Anymore Rick Hong, MD Associate Chairman CCHS EMC Medical Director, PHPS.

Avian Influenza: A Zoonotic Disease of International Importance 1.

Review Questions 1. What is the most common infection? Answer: The cold 2. What are the 2 surface proteins on the flu virus? Answer: H = Haemagglutinin.

Agilent Restricted Influenza H1N1 A (Swine Influenza) Information for Agilent’s Employees.

Swine Flu. History First isolated in North America in 2009 Mortality rate was lower than other pandemics First pandemic of the 21 st Century.

Bioinformatics A Summary seminar (with many hints for exam questions)

Influenza A (H1N1). What is Influenza A (H1N1)? Influenza A(H1N1) is caused by a novel virus that resulted from the reassortment of 4 viruses from pigs,

SWINE FLU. WHAT IS SWINE FLU? Swine Influenza (swine flu) is a respiratory disease of Type A influenza viruses that causes regular outbreaks in pigs.

Objectives: Define the term emerging disease Identify five reasons why diseases emerge.

Seasonal Influenza and Pandemic Influenza A (H1N1, H5N1) Virus Dr. Alaa kuttar musa Department of Medicine College of Medicine/ Basra University.

Viagra is used to treat men with erectile dysfunction, also called impotence. In this condition does not occur in men normal erection necessary.

Cross-Species Transmission of Avian Influenza (H5N1) to Humans

Antiviral Medications

An window on Bird Flu.

Antivirals Essential idea

Avian Influenza A (H5N1) “Bird Flu”

Presentation on Viral flu

Influenza Virus: Evolution in real time

Spread, Treatment, and Prevention of Disease

What makes H5N1 Avian influenza “Avian”

Influenza يك بيماري بسيار مسري عفوني ويروسي است.

Viruses Small but deadly!.

Infectious Disease.

وبائية أنفلونزا الطيور والإجراءات المتخذة لمواجهة الوباء العالمي

KEY CONCEPT Entire genomes are sequenced, studied, and compared.

KEY CONCEPT Entire genomes are sequenced, studied, and compared.

Section 21.4 Emerging Infectious Diseases Objectives

DEPARTMENT OF MEDICINE, UOM

KEY CONCEPT Entire genomes are sequenced, studied, and compared.

KEY CONCEPT Entire genomes are sequenced, studied, and compared.

Avian influenza ( Bird flu )

Presentation transcript:

Bioinformatics Necessary evil, panacea, or just a useful tool? With a month in the lab you can easily prevent having to sit an hour in front of the computer. Nothing is impossible for a biologist who doesn’t have to discover it him/her-self.

Bio + informatica

Humaan genoom

Humaan genoom ....acccaagaagtcagaatcctcgaagctgaagcctgactgtaatcctcgaagctgaagcctgactgtaagctctgcctcctac aactaatcctcgaagctgaagcctgactgtagacaagtcacaatgcaacccctttgctccagaggaaaaggagtaagcacagaggg cttctgagtccggcaatgctcaatcctcgaagctgaagcctgactgtcatttcctgacaggagcattttacagacttgcgtctgcc cctctgagggaggcagggccatcagctaacactcagagacaatcctcgaagctgaagcctgactgtaaggatggtcctacaacatc ctgatctgggaggaagaggtgaaggcaactcaccaccctaatcctcgaagctgaagcctgactgtaatcctcgactgtcaggcaaca gtggaactaaggctcattctaaagaatgtgcccaagatcaaatcctcgaagctgaagcctgactgtcacaccgaaggctgcaaagc gagagtcaaacttggaatcttaacagaaaccctgaacctgcacttgtccctttacactgctcttaacagaaacctgcagcatgg atgcgatggctgggcagagggaagtgcccaagcctgaatcctcgaagctgaagcctgactgtgggacaaaaatgcctacctg....

Chromosomes

Genome annotation

Bioinformatics and medicines One day we know everything about all human (and flu) proteins and then can we start to ‘calculate’ flu-medicines.

Drug Design

GPCR

Drug Design

Mens vs parasiet Parasite Active site

Medicine Every small molecule is, in principle, a poison. We call it a flu-medicine if it kills the flu much faster than the patient.

H1N1 / H5N1

H1N1

Strange mortality 1918 (the 1918 flu was H1N1)

Same strange mortality in Mexican H1N1? Why?

Flu bioinformatics Determine which variant it is from sequence comparisons Design medicine(s) (tamivir, etc) Determine why H1N1 is dangerous Predict next variant

Bird/pig flu

Pig flu pandemic?

H5N1 (but H1N1 also went through birds)

Neuraminidase Quote from Wikipedia/WHO/etc: On February 27, 2005, a 14-year-old Vietnamese girl was documented to be carrying an H5N1 influenza virus strain that was resistant to the drug oseltamivir. However, the Vietnamese girl who had received a prophylactic dose (75 mg once a day) was found to be non-responsive to the medication. In growing fears of a global avian flu pandemic, scientists began to look for a cause of resistance to the Tamiflu medication. The cause was determined to be a histidine-to-tryosine substitution at position 274 in its neuraminidase protein.

H1N1 medicijn