Allergenic significance of cephalosporin side chains

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Presentation transcript:

Allergenic significance of cephalosporin side chains Brian A. Baldo, PhD, Nghia H. Pham, PhD Journal of Allergy and Clinical Immunology Volume 136, Issue 5, Pages 1426-1428 (November 2015) DOI: 10.1016/j.jaci.2015.06.051 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 General structure of cephalosporins and structures of cephalosporins used in the study1 showing the R1 methoxyimino group (magenta) and the R2 ester and thioether groups (blue and red, respectively). Space-filling models show that, compared with cefodizime, the thioether group of ceftriaxone is at least partially hindered by the adjacent ring N-methyl group, perhaps impeding IgE binding. Journal of Allergy and Clinical Immunology 2015 136, 1426-1428DOI: (10.1016/j.jaci.2015.06.051) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions