Comparison of the effect of oral and transdermal hormone therapy on fasting and postmethionine homocysteine levels Angelo Cagnacci, M.D., Stefania Malmusi,

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Comparison of the effect of oral and transdermal hormone therapy on fasting and postmethionine homocysteine levels Angelo Cagnacci, M.D., Stefania Malmusi, M.D., Anna Lisa Zanni, M.D., Chiara Alessandrini, M.D., Simona Caretto, M.D., Annibale Volpe, M.D. Fertility and Sterility Volume 81, Issue 1, Pages 99-103 (January 2004) DOI: 10.1016/j.fertnstert.2003.05.026

FIGURE 1 Regression analysis between levels of homocysteine (Hcy; top panel) or the ratio homocysteine/cysteine (Hcy/Cys; bottom panel) and the net modifications induced by continuous combined E2 plus norethisterone administered for 6 months by a transdermal (open circles) or an oral (closed circles) route. Cagnacci. Homocysteine levels and HT. Fertil Steril 2004. Fertility and Sterility 2004 81, 99-103DOI: (10.1016/j.fertnstert.2003.05.026)

FIGURE 2 Difference between postoral methionine load and basal Hcy values observed in basal condition and after continuous combined E2 plus norethisterone administered for 6 months by an oral (left panel) or transdermal (right panel) route. Values are reported as the median of the values. The boxes show the 25th to 75th percentiles and the lines the 10th to 90th percentiles. *P<.05; †P<.02 vs. the corresponding before, by Wilcoxon signed-rank test. Cagnacci. Homocysteine levels and HT. Fertil Steril 2004. Fertility and Sterility 2004 81, 99-103DOI: (10.1016/j.fertnstert.2003.05.026)