Arjunolic acid attenuates arsenic-induced nephrotoxicity

Slides:

Advertisements

Similar presentations

Modulation of circulating cell–endothelial cell interaction by erythropoietin in lean and obese mice with cecal ligation and puncture Vidula Vachharajani,

Advertisements

The antioxidant and cytoprotective activity of Ocimum gratissimum extracts against hydrogen peroxide-induced toxicity in human HepG2 cells Yung-Wei Chiu,

Volume 16, Issue 2, Pages (August 2009)

Volume 21, Issue 2, Pages (June 2014)

Joydeep Das, Jyotirmoy Ghosh, Prasenjit Manna, Parames C. Sil

Traditional extract of Pithecellobium dulce fruits protects mice against CCl4 induced renal oxidative impairments and necrotic cell death Pabitra Bikash.

Schwann cell injuries of radial nerve after lead (Pb) exposure in rats

The role of lymphatic vessels in the heart

Garlic extract reduces serum angiotensin converting enzyme (ACE) activity in nondiabetic and streptozotocin-diabetic rats Mahmoud Hosseini, S. Mohammad.

Hypoglycemic and hypolipidemic effect and antioxidant activity of chronic epigallocatechin-gallate in streptozotocin-diabetic rats Mehrdad Roghani, Tourandokht.

A 43kD protein from the herb, Cajanus indicus L

Anandita Roy, Parames C. Sil Pathophysiology

Ewa Kus, Andrzej Bienkiewicz Pathophysiology

Volume 24, Issue 2, Pages (June 2017)

Volume 19, Issue 2, Pages (April 2012)

Mary Chatterjee, Kasturi Sarkar, Parames C. Sil Pathophysiology

Volume 21, Issue 3, Pages (September 2014)

Amelioration of pancreatic and renal derangements in streptozotocin-induced diabetic rats by polyphenol extracts of Ginger (Zingiber officinale) rhizome

Volume 11, Issue 2, Pages (October 2004)

Volume 18, Issue 2, Pages (April 2011)

Omega-3 fatty acids decreases oxidative stress, tumor necrosis factor-alpha, and interleukin-1 beta in hyperthyroidism-induced hepatic dysfunction rat.

Oxidative stress in autism

Hepatoprotective properties of kombucha tea against TBHP-induced oxidative stress via suppression of mitochondria dependent apoptosis Semantee Bhattacharya,

M. Kankofer, J. Lipko, S. Zdunczyk Pathophysiology

Volume 18, Issue 4, Pages (September 2011)

Ontogeny of pulmonary cyclooxygenase-1 (COX-1) and -2 (COX-2)

Doruk Erkan, Elizabeth Kozora, Michael D. Lockshin Pathophysiology

Volume 21, Issue 2, Pages (June 2014)

Increasing rates of head melanoma in Nordic countries

Volume 24, Issue 1, Pages 1-8 (March 2017)

Volume 15, Issue 4, Pages (December 2008)

Paraoxonase-1 (PON1) inhibition by tienilic acid produces hepatic injury: Antioxidant protection by fennel extract and whey protein concentrate Khaled.

Mrinal K. Sarkar, Parames C. Sil Pathophysiology

Synovial biology and T cells in rheumatoid arthritis

Possible mechanisms of Cyclosporin A ameliorated the ischemic microenvironment and inhibited mitochondria stress in tree shrews’ hippocampus Shu-qing.

Serum cholinesterase activity in the diagnosis of nonalcoholic fatty liver disease in type 2 diabetic patients O.O. Ogunkeye, E.K. Chuhwak, A.A.E. Otokwula

Michael T. LeVasseur, Neal D. Goldstein, Seth L. Welles

Vitamin D reduces high-fat diet induced weight gain and C-reactive protein, increases interleukin-10, and reduces CD86 and caspase-3 Asmaa M.S. Gomaa,

Volume 22, Issue 3, Pages (September 2015)

Folic acid protects against lead acetate-induced hepatotoxicity by decreasing NF-κB, IL- 1β production and lipid peroxidation mediataed cell injury Eman.

Volume 11, Issue 2, Pages (October 2004)

Heart rhythm disturbances in the neonatal alloxan-induced diabetic rat

Influence of obesity on sepsis

L-Arginine supplementation enhances antioxidant activity and erythrocyte integrity in sickle cell anaemia subjects M.O. Kehinde, S.I. Ogungbemi, C.N.

Volume 15, Issue 3, Pages (October 2008)

Cardiac and autonomic responses to change in posture or vitamin C supplementation in sickle cell anemia subjects S.I. Jaja, M.O. Kehinde, S.I. Ogungbemi

Volume 19, Issue 1, Pages (February 2012)

Kasturi Sarkar, Parames C. Sil Pathophysiology

Volume 19, Issue 4, Pages (September 2012)

Volume 20, Issue 4, Pages (September 2013)

Yanjie He, Tianhan Kong, Weihua Dong Pathophysiology

Magnesium transport in hypertension

Catherine J. Hunter, Isabelle G. De Plaen Pathophysiology

Current concepts in the surgical approach to necrotizing enterocolitis

Volume 19, Issue 3, Pages (June 2012)

Volume 20, Issue 3, Pages (June 2013)

Natural and hybrid (“chimeric”) stable regulatory glyproline peptides

David A. Clark, Upender K. Munshi Pathophysiology

Volume 16, Issue 1, Pages (June 2009)

Volume 18, Issue 2, Pages (April 2011)

Angiotensin converting enzyme inhibitor captopril modifies conditioned place preference induced by morphine and morphine withdrawal signs in rats Hojjatallah.

Skin cancer epidemic in a wireless world

Zhiyong Ming, Seppo Pietikainen, Osmo Hänninen Pathophysiology

Increasing incidence of brain tumours in sparsely populated areas

The impact of psychogenic stressors on oxidative stress markers and patterns of CYP2E1 expression in mice liver Oksana Maksymchuk, Mykola Chashchyn

Age and cerebral circulation

Volume 14, Issue 1, Pages (May 2007)

The effect of maintenance and reversal of DOCA-Salt hypertension on extravasation of macromolecules and serum nitric oxide concentration in male rats

Low dietary folate impairs glucose tolerance and plasma lipid profile in oral contraceptive-treated rats L.A. Olatunji, A.O. Soladoye Pathophysiology

Risk factors and mechanisms of non-alcoholic steatohepatitis

Presentation transcript:

Arjunolic acid attenuates arsenic-induced nephrotoxicity Mahua Sinha, Prasenjit Manna, Parames C. Sil Pathophysiology Volume 15, Issue 3, Pages 147-156 (October 2008) DOI: 10.1016/j.pathophys.2008.03.001 Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 The chemical structure of arjunolic acid (AA). Pathophysiology 2008 15, 147-156DOI: (10.1016/j.pathophys.2008.03.001) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 DPPH radical scavenging activity of AA in cell-free system. The curve is obtained by plotting various concentrations of AA against percent inhibition of DPPH radical. Pathophysiology 2008 15, 147-156DOI: (10.1016/j.pathophys.2008.03.001) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Dose-dependent effect of AA on intracellular antioxidant power against As-induced toxicity in the kidney of the mice treated with NaAsO2. Cont, antioxidant power in normal mice; As, antioxidant power in As-treated mice, AA-5+As, AA-10+As, AA-15+As, AA-20+As, AA-25+As; AA-50+As: antioxidant power in AA-treated mice for 4 days at a dose of 5, 10, 15, 20, 25 and 50mg/kg body weight prior to As administration. Each column represents mean±S.D., n=6. Pathophysiology 2008 15, 147-156DOI: (10.1016/j.pathophys.2008.03.001) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Haematoxylin and eosin stained hepatic section of (A) normal mice kidney (20×), (B) toxin (NaAsO2) control, (C) AA pretreated kidney section before NaAsO2 administration (20×) and (D) vitamin C pretreated kidney section before NaAsO2 administration (20×). Pathophysiology 2008 15, 147-156DOI: (10.1016/j.pathophys.2008.03.001) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions