Ovarian stimulation leads to a severe implantation defect in mice

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Ovarian stimulation leads to a severe implantation defect in mice Shaorong Deng, Jing Xu, Jianwu Zeng, Linli Hu, Yunxia Wu  Reproductive BioMedicine Online  Volume 27, Issue 2, Pages 172-175 (August 2013) DOI: 10.1016/j.rbmo.2013.03.018 Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 External morphology of naturally pregnant mice (NP) (A–C) and stimulated mice (10.0IU pregnant mare serum gonadotrophin and human chorionic gonadotrophin; D–F) implantation sites during peri- and post-implantation as visualized with a dissecting light microscope. Note the peri-implantation sites (A, D; white arrows), viable post-implantation sites in naturally pregnant mice (B, C; V and black arrows) and the resorbed post-implantation sites with relatively smaller size in stimulated mice (E, F; R and black arrows). C and F show at higher magnification the typically observed differences in the external appearance of viable implantation sites and resorbed implantation sites on pregnancy day (PD) 8. (G, H) Mean percentage±SEM peri-implantation embryo loss on PD5 (G) and post-implantation resorption on PD8 (H). Bars=5mm. Reproductive BioMedicine Online 2013 27, 172-175DOI: (10.1016/j.rbmo.2013.03.018) Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions