Liam O’Mahony, PhD, Mübeccel Akdis, MD, PhD, Cezmi A. Akdis, MD

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Presentation transcript:

Regulation of the immune response and inflammation by histamine and histamine receptors Liam O’Mahony, PhD, Mübeccel Akdis, MD, PhD, Cezmi A. Akdis, MD Journal of Allergy and Clinical Immunology Volume 128, Issue 6, Pages 1153-1162 (December 2011) DOI: 10.1016/j.jaci.2011.06.051 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Histamine influences DC migration (H4R) and cytokine secretion, resulting in increased IL-12 (H1R) or IL-10 (H2R) responses. H1R is expressed by TH1 cells, and histamine further promotes the TH1 program by enhancing IFN-γ secretion. H2R suppresses both TH1 and TH2 functions while promoting the potency of Treg cells. H4R is expressed on certain leukocytes as an important chemotactic receptor. H3R activation on neuronal cells results in altered neurotransmitter release, with subsequent effects on T-cell chemokine release. Journal of Allergy and Clinical Immunology 2011 128, 1153-1162DOI: (10.1016/j.jaci.2011.06.051) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions