Fontan Failure and Death in Contemporary Fontan Circulation: Analysis From the Last Two Decades Yasuhiro Kotani, MD, PhD, Devin Chetan, MD, Jiaquan Zhu,

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Fontan Failure and Death in Contemporary Fontan Circulation: Analysis From the Last Two Decades Yasuhiro Kotani, MD, PhD, Devin Chetan, MD, Jiaquan Zhu, MD, PhD, Arezou Saedi, MD, Lisa Zhao, BSc, BScN, Luc Mertens, MD, PhD, Andrew N. Redington, MBBS, John Coles, MD, Christopher A. Caldarone, MD, Glen S. Van Arsdell, MD, Osami Honjo, MD, PhD The Annals of Thoracic Surgery Volume 105, Issue 4, Pages 1240-1247 (April 2018) DOI: 10.1016/j.athoracsur.2017.10.047 Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Kaplan-Meier analysis for freedom from death/transplant (A) in the whole cohort and (B) stratified by era: 1985 to 1998 (n = 200 [blue]) and 1999 to 2012 (n = 300 [red]. Survival has significantly improved over time. The Annals of Thoracic Surgery 2018 105, 1240-1247DOI: (10.1016/j.athoracsur.2017.10.047) Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Timing and mode of death between early era (1985 to 1998) and recent era (1999 to 2012). Circulatory failure and multiorgan failure (MOF) leading to early death (blue bars) have been overcome in the recent era, yet causes of late death (red bars) have remained unchanged. The Annals of Thoracic Surgery 2018 105, 1240-1247DOI: (10.1016/j.athoracsur.2017.10.047) Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Kaplan-Meier analysis for freedom from late Fontan complication stratified by mortality among hospital survivors. There was a significant difference in freedom from late Fontan complication between patients who are alive (n = 460) and patients who died (n = 17). The Annals of Thoracic Surgery 2018 105, 1240-1247DOI: (10.1016/j.athoracsur.2017.10.047) Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions