Nutrigenomics KNH 413

Nutrigenomics and Disease Cancer Use of omega-3 & EPA for rare types Predicting benefit difficult in other types Responders and non-responders Colon cancer Folate intake and alcohol Fruits and vegetables Breast cancer Antioxidants

Nutrigenomics and Disease Obesity Susceptibility with conducive environment Polygenic trait Promising research Perilipin Serotonin receptor gene promoter

Nutrigenomics and Disease Thrifty Gene hypothesis Metabolic status and fetal adaptation predict disease in adulthood Proneness to metabolic syndrome, obesity, diabetes, CVD

Nutrigenomics and Disease Diabetes Focus on type 2 Metabolic syndrome, insulin resistance GLUT 2 PPARy APOE

Nutrigenomics and Disease Cardiovascular Disease Dyslipidemias Familial hypercholesterolemia PUFAs on HDL Omega-3s and TG Omega-6s and inflammation

Dietetics and Genetics Understanding nutrient interactions and genes Future of diet counseling Beware of home testing kits “DNA diet” Sciona Costly EGAPP Project To establish a coordinated process