Fig. 4. Acute lung injury in miR-223−/y mice.

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Fig. 4. Acute lung injury in miR-223−/y mice. Acute lung injury in miR-223−/y mice. WT and miR-223−/y mice were exposed to VILI. (A) Albumin detected in mouse BAL fluid was measured in WT and miR-223−/y mice (means ± SEM; n = 5 mice in the WT control group and n = 7 mice in all others groups). (B) The neutrophil enzyme myeloperoxidase (MPO) was measured in BAL fluid from WT and miR-223−/y mice (means ± SEM; n = 5 mice in the WT VILI group and n = 6 mice in all others groups). (C and D) Interleukin-6 (IL-6) and Cxcl-1 protein concentrations in BAL fluid from WT and miR-223−/y mice were measured by enzyme-linked immunosorbent assay (ELISA) [means ± SEM; (C) n = 6 mice in the control group, n = 13 mice in the WT VILI group, and n = 12 mice in the miR-223−/y VILI group; (D) n = 6 mice in the control group, n = 8 mice in the WT VILI group, and n = 13 mice in the miR-223−/y VILI group]. (E) Representative slides of pulmonary histology for WT and miR-223−/y mice [hematoxylin and eosin (H&E) staining]. Scale bar, 100 μm. (F) Scoring of lung injury in slides from (E). (G and H) Pulmonary PARP-1 protein expression in WT or miR-223−/y mice at baseline (Ctr) or during acute lung injury (VILI) relative to the housekeeping gene β-actin (one representative blot of three is shown; quantification by densitometry, n = 3). (I) PARP-1 enzyme activity in WT or miR-223−/y mice (n = 5 mice in the miR-223−/y VILI group or n = 4 mice for all other groups). HPF, high-power field. (J) Representative immunohistochemical staining for PARP-1 activity in WT and miR-223−/y mice (*P < 0.05, ANOVA). Viola Neudecker et al., Sci Transl Med 2017;9:eaah5360 Published by AAAS