Mitosis sans Mitosis: The Mitotic Oscillator in Differentiation

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Mitosis sans Mitosis: The Mitotic Oscillator in Differentiation Miranda Stratton, Tim Stearns Developmental Cell Volume 43, Issue 4, Pages 385-386 (November 2017) DOI: 10.1016/j.devcel.2017.11.001 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 The Multiciliated Cell Differentiation Pathway Is Regulated by Mitotic Regulators Centriole formation during ciliogenesis in multiciliated precursor cells occurs through three phases, as shown in the top panel. In amplification, centrioles (yellow) are formed from deuterosomes (orange) and from preexisting centrioles. During growth, centrioles elongate to their full length. In disengagement, centrioles separate from their nucleating structures, going on to dock to the apical membrane and form motile cilia. Al Jord et al. (2017) found that progression through these phases is regulated by Cdk1, Plk1, and anaphase-promoting complex (APC/C) activity. The bottom panel shows the consequences of misregulation. These results suggest that Cdk1 activity drives the centriole formation process in multiciliated cell differentiation but that its activity is dampened to prevent mitotic entry. Developmental Cell 2017 43, 385-386DOI: (10.1016/j.devcel.2017.11.001) Copyright © 2017 Elsevier Inc. Terms and Conditions