A Vitamin for Autophagy

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Presentation transcript:

A Vitamin for Autophagy Mario Fabri, Robert L. Modlin Cell Host & Microbe Volume 6, Issue 3, Pages 201-203 (September 2009) DOI: 10.1016/j.chom.2009.08.008 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Model for the Role of Autophagy in the Vitamin D-Dependent Induction of Antimicrobial Responses in Humans TLR2/1 ligation induces IL-15, leading to the upregulation of the VDR and CYP27b1. CYP27b1 hydroxylates the inactive form of vitamin D (25D3) into the active form (1,25D3), which mediates the upregulation of antimicrobial peptides cathelicidin (Cath.) and (together with induction by IL-1) human β-defensin 2 (DEFB4). As shown by Yuk et al., cathelicidin also induces autophagy and colocalizes with M. tuberculosis in autophagolysosomes, leading to killing of the bacterium. Lysosomal ubiquitin-derived peptides contribute to antimicrobial activity. Cell Host & Microbe 2009 6, 201-203DOI: (10.1016/j.chom.2009.08.008) Copyright © 2009 Elsevier Inc. Terms and Conditions