Sitarina Widyarini, Munif Allanson, Nerida L

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Presentation transcript:

Isoflavonoid Photoprotection in Mouse and Human Skin Is Dependent on Metallothionein Sitarina Widyarini, Munif Allanson, Nerida L. Gallagher, Julie Pedley, Glen M. Boyle, Peter G. Parsons, David C. Whiteman, Catherine Walker, Vivienne E. Reeve Journal of Investigative Dermatology Volume 126, Issue 1, Pages 198-204 (January 2006) DOI: 10.1038/sj.jid.5700013 Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Average contact hypersensitivity responses in groups of five MT+/+ or MT-/- mice irradiated (or not) with SSUV, followed by topical applications of base lotion or equol lotions of increasing concentration. Bars represent SEM. %I/S=% immunosuppression. Journal of Investigative Dermatology 2006 126, 198-204DOI: (10.1038/sj.jid.5700013) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Average contact hypersensitivity responses in groups of five MT+/+ or MT-/- mice treated (or not) with topical cis-urocanic acid (c-UCA), followed by topical applications of base lotion or 10.0μM equol lotion. Bars represent SEM. Journal of Investigative Dermatology 2006 126, 198-204DOI: (10.1038/sj.jid.5700013) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Semi-quantitative image analysis of average MT-1 mRNA in mouse skin, normalized against heme oxygenase-2. Mice were treated with base lotion (BL), SSUV, 10.0μM equol lotion (equol), or SSUV+equol lotion. Bars represent SD for n=3 mice. Journal of Investigative Dermatology 2006 126, 198-204DOI: (10.1038/sj.jid.5700013) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Immunohistochemical identification of MT in mouse skin (brown staining) treated topically with base lotion or 10μM equol lotion, before and at 72hours post-SSUV exposure. Staining indicates immunopositive basal epidermal cells post-SSUV, with strongly enhanced epidermal staining after SSUV+equol lotion. Dermal dendritic cells expressed MT following SSUV, but were less evident following SSUV+equol lotion. Magnification × 20. Journal of Investigative Dermatology 2006 126, 198-204DOI: (10.1038/sj.jid.5700013) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 5 Immunohistochemical identification of MT in human skin (red staining) before treatment (Nil) and at 24hours post-SSUV followed by base lotion or 200μM NV-07α lotion. Staining indicates constitutive basal epidermal MT expression in untreated skin, increased epidermal staining post-SSUV, and strongly enhanced epidermal staining after SSUV+NV-07α lotion. Dermal dendritic cells expressed MT following SSUV as well as SSUV+NV-07α. Magnification × 20; dermis × 40. Journal of Investigative Dermatology 2006 126, 198-204DOI: (10.1038/sj.jid.5700013) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions