Volume 115, Issue 1, Pages (July 1998)

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Volume 115, Issue 1, Pages 116-123 (July 1998) Propranolol plus prazosin compared with propranolol plus isosorbide-5-mononitrate in the treatment of portal hypertension Agustín Albillos*, Juan–Carlos García–Pagán‡, Jerónimo Iborra*, Juan–Carlos Bandi‡, Guillermo Cacho*, María Pérez–Paramo§, Angels Escorsell‡, José Luis Calleja*, Pedro Escartín*, Jaime Bosch‡ Gastroenterology Volume 115, Issue 1, Pages 116-123 (July 1998) DOI: 10.1016/S0016-5085(98)70372-5 Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 1 Individual values of HVPG at baseline and after 3 months of (A) propranolol plus prazosin or (B) propranolol plus ISMN. The horizontal bars represent the mean, and the rectangles represent the SEM. A significantly greater reduction in HVPG was observed with propranolol plus prazosin than with propranolol plus ISMN. At 3 months, the final value of HVPG was significantly lower in patients receiving propranolol plus prazosin (P < 0.05). Gastroenterology 1998 115, 116-123DOI: (10.1016/S0016-5085(98)70372-5) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 2 Relative HVPG decreases (mean ± SEM) after short-term intravenous propranolol administration (□) and after long-term administration of propranolol plus prazosin (■) or propranolol plus ISMN (▨). (A) Combination therapy did not further decrease the HVPG in propranolol responders, but (B) both drug combinations enhanced the decrease in HVPG in propranolol nonresponders. The reduction of HVPG caused by propranolol plus prazosin was significantly greater than that by propranolol plus ISMN. Gastroenterology 1998 115, 116-123DOI: (10.1016/S0016-5085(98)70372-5) Copyright © 1998 American Gastroenterological Association Terms and Conditions