Anu Dham, MD, Alexander M. Truskinovsky, MD, Arkadiusz Z

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Thymic Carcinoid Responds to Neoadjuvant Therapy with Sunitinib and Octreotide: A Case Report Anu Dham, MD, Alexander M. Truskinovsky, MD, Arkadiusz Z. Dudek, MD, PhD Journal of Thoracic Oncology Volume 3, Issue 1, Pages 94-97 (January 2008) DOI: 10.1097/JTO.0b013e31815eb7a2 Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Lobulated, heterogenous, mediastinal, soft-tissue mass (8.3 × 5.0 cm) with right hilar lymphadenopathy. Mass was measured at the level of branching of the main pulmonary artery. Journal of Thoracic Oncology 2008 3, 94-97DOI: (10.1097/JTO.0b013e31815eb7a2) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Needle biopsy specimen of the mediastinal mass. (Hematoxylin and eosin, original magnification ×400.) Journal of Thoracic Oncology 2008 3, 94-97DOI: (10.1097/JTO.0b013e31815eb7a2) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Decrease in size of anterior mediastinal mass (7.7 × 4.5) after 3 weeks of sunitinib and octreotide therapy. Mass was measured at the level of branching of the main pulmonary artery. Journal of Thoracic Oncology 2008 3, 94-97DOI: (10.1097/JTO.0b013e31815eb7a2) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 Tumor in the resection specimen of the right lung. Arrows mark mitotic figures. (Hematoxylin and eosin, original magnification ×400.) Journal of Thoracic Oncology 2008 3, 94-97DOI: (10.1097/JTO.0b013e31815eb7a2) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 5 Diffuse, strong positive immunostaining of the tumor for synaptophysin. (Synaptophysin immunostain, original magnification ×200.) Journal of Thoracic Oncology 2008 3, 94-97DOI: (10.1097/JTO.0b013e31815eb7a2) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 6 Moderately increased Ki67 (proliferative) index of the tumor in the resection specimen. (Ki67 immunostain, original magnification ×200.) Journal of Thoracic Oncology 2008 3, 94-97DOI: (10.1097/JTO.0b013e31815eb7a2) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions