Immunohistochemical and serological evidence for the role of streptococcal proteinase in acute post-streptococcal glomerulonephritis Gil A. Cu, Sergio.

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Immunohistochemical and serological evidence for the role of streptococcal proteinase in acute post-streptococcal glomerulonephritis Gil A. Cu, Sergio Mezzano, Jason D. Bannan, John B. Zabriskie Kidney International Volume 54, Issue 3, Pages 819-826 (September 1998) DOI: 10.1046/j.1523-1755.1998.00052.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 (A) Anti-SPEB titers in sera from patients with acute post-streptococcal glomerulonephritis (APSGN), acute rheumatic fever (ARF), scarlet fever (SF) and normal children.*P < 0.001. (B) ASO titers from the same group of patients, indicating a definite serological response to a streptococcal extracellular product in the streptococcal infections groups. *P < 0.001 for AGN, ARF and SF vs. normals. P = NS vs. AGN, ARF and SF. Kidney International 1998 54, 819-826DOI: (10.1046/j.1523-1755.1998.00052.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Serial anti-SPEB titers in the sera of patients with APSGN. N = 13 cases. Kidney International 1998 54, 819-826DOI: (10.1046/j.1523-1755.1998.00052.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Comparison of anti-SPEB titers between convalescent APSGN sera (after 1year) and normal sera. P < 0.0001 by the t-test. Kidney International 1998 54, 819-826DOI: (10.1046/j.1523-1755.1998.00052.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Immunofluorescent staining of kidney biopsy section of one case of APSGN using different antibodies (×40). (A) Extensive deposition of C3 in mesangium and glomerular capillary walls. (B and C) Minimal staining for IgG and IgM. (D) shows extensive deposition of SPEB in mesangium and glomerular capillary wall. Staining for SPEB can be abolished by pre-absorbing the rabbit sera against purified SPEB (E). (F) The absence of SPEB in a non-APSGN kidney biopsy section. (case of IgA nephropathy). Kidney International 1998 54, 819-826DOI: (10.1046/j.1523-1755.1998.00052.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 819-826DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 819-826DOI: (10.1046/j.1523-1755.1998.00052.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 819-826DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 819-826DOI: (10.1046/j.1523-1755.1998.00052.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 819-826DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 819-826DOI: (10.1046/j.1523-1755.1998.00052.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 819-826DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 819-826DOI: (10.1046/j.1523-1755.1998.00052.x) Copyright © 1998 International Society of Nephrology Terms and Conditions