Do old pharmacokinetic parameter estimates predict new data?

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Presentation transcript:

Do old pharmacokinetic parameter estimates predict new data? B.J. Anderson, J. McLay, K. Allegaert, T. Engelhardt British Journal of Anaesthesia Volume 109, Issue 6, Pages 1013-1014 (December 2012) DOI: 10.1093/bja/aes414 Copyright © 2012 The Author(s) Terms and Conditions

Fig 1 Prediction-corrected visual predictive check using parameter estimates from an earlier study5 and observations from the new study.2 All plots show the median and 90% intervals (solid and dashed lines). (a) shows all prediction-corrected observed concentrations. (b) shows prediction corrected percentiles (10%, 50%, and 90%) for observations (lines with symbols) and predictions (lines) with 95% confidence intervals for prediction percentiles (green-shaded areas). British Journal of Anaesthesia 2012 109, 1013-1014DOI: (10.1093/bja/aes414) Copyright © 2012 The Author(s) Terms and Conditions