New insights into the pathogenesis of proteinuria Richard J. Johnson, MD  American Journal of Kidney Diseases  Volume 36, Issue 1, Pages 214-216 (July 2000) DOI: 10.1053/ajkd.2000.8296 Copyright © 2000 National Kidney Foundation, Inc Terms and Conditions

Fig 1 Proposed slit diaphragm morphology and structure. In the original paper by Rodewald and Karnovsky,4 the slit diaphragm was shown to be a zipper-like structure by electron micrography (A) and was postulated to be approximately 39 nm in width with a central filament and flanking crossbridges with intervening 4 × 14 nm pores (B). As proposed by Tryggvasson,23 the new molecular model for the slit diaphragm consists of nephrin molecules from opposing foot processes interdigitating their Ig repeats 1 through 6, thus forming the central zipper-like structure observed in the electron microscopy studies (C). The X marks the position of a possible site for an anchoring protein for the nephrin molecule. (Reprinted with permission from Rodewald and Karnovsky4 [A, B] and Tryggvasson23 [C]. [A] and [B] are reproduced from The Journal of Cell Biology , 1974, vol. 60, pp. 423-433, by copyright permission of The Rockefeller University Press.) American Journal of Kidney Diseases 2000 36, 214-216DOI: (10.1053/ajkd.2000.8296) Copyright © 2000 National Kidney Foundation, Inc Terms and Conditions