Exogenous surfactant treatment before and after sixteen hours of ischemia in experimental lung transplantation Bernard Hausen, MDa, Roland Rohde, MDa,

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Presentation transcript:

Exogenous surfactant treatment before and after sixteen hours of ischemia in experimental lung transplantation Bernard Hausen, MDa, Roland Rohde, MDa, Charles W. Hewitt, PhDb, Frank Schroeder, a, Maike Beuke, a, Raj Ramsamooj, MDb, Hans-Joachim Schäfers, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 113, Issue 6, Pages 1050-1058 (June 1997) DOI: 10.1016/S0022-5223(97)70292-7 Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Experimental setup of the acute double lung transplantation model. A donor lung is connected to a syngeneic recipient animal with two specially designed stents. The donor lung is ventilated separately. A pneumotachograph with analog/digital converters allows isolated determination of donor lung function. The analog/digital converter is connected to a computer for online data recording and display. The side ports of both stents are used for pressure measurement and blood retrieval for gas measurements. PAP, Pulmonary artery pressure; LAP, left atrial pressure. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 1050-1058DOI: (10.1016/S0022-5223(97)70292-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 2 Dynamic pulmonary compliance measured in 20-minute intervals. Repeated-measures ANOVA comparison between group I (control group), group II (recipient treatment 200 mg/kg dose of surfactant), group III (donor treatment 20 mg/kg dose of surfactant), and group IV (donor treatment 200 mg/kg dose of surfactant) (ANOVA: group I vs group IV, p < 0.02; group II vs group IV, p < 0.04; group III vs group IV, p < 0.02). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 1050-1058DOI: (10.1016/S0022-5223(97)70292-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 3 Resistance to pulmonary air flow measured in centimeters of water per liter per second. Repeated-measures ANOVA for group effect: group I versus group IV, p < 0.04; group II versus group IV, p < 0.05; group III versus group IV, p < 0.02. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 1050-1058DOI: (10.1016/S0022-5223(97)70292-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 4 Comparison of alveolar-arterial oxygen difference. Donor treatment with exogenous surfactant with either 20 or 200 mg/kg improves graft function with respect to oxygenation (group I vs group IV, p < 0.05; group II vs group IV, p < 0.02; group III vs group IV, p < 0.01). The Journal of Thoracic and Cardiovascular Surgery 1997 113, 1050-1058DOI: (10.1016/S0022-5223(97)70292-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 5 The vascular resistance to pulmonary blood flow measured in millimeters of mercury per minute per milliliter is markedly elevated in group I and group II. Pulmonary vascular resistance changed significantly over time in group I (repeated-measures ANOVA: p < 0.05), group II (p < 0.04), and group IV (p < 0.0006). Repeated-measures ANOVA for group effect: group I versus group IV, p < 0.05; group II versus group IV, p < 0.04; group III versus group IV, p < 0.3. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 1050-1058DOI: (10.1016/S0022-5223(97)70292-7) Copyright © 1997 Mosby, Inc. Terms and Conditions