Epigenetic modifications as new targets for liver disease therapies Müjdat Zeybel, Derek A. Mann, Jelena Mann  Journal of Hepatology  Volume 59, Issue 6, Pages 1349-1353 (December 2013) DOI: 10.1016/j.jhep.2013.05.039 Copyright © 2013 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Epigenetic mechanisms that regulate gene expression. The mammalian genome is packaged in the nucleus via wrapping of DNA around histones, forming a structure known as chromatin. The on and off state of gene expression is regulated by DNA methylation, post-translational modifications of various residues within histone tails, and non-coding RNAs. Journal of Hepatology 2013 59, 1349-1353DOI: (10.1016/j.jhep.2013.05.039) Copyright © 2013 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Enzymes that control histone lysine methylation and acetylation are targets for numerous drugs that are being developed or already used clinically. HDAC, histone deacetylase; HAT, histone acetyltransferase; KMT, histone lysine methyltransferas; KDM, histone lysine demethylase. Journal of Hepatology 2013 59, 1349-1353DOI: (10.1016/j.jhep.2013.05.039) Copyright © 2013 European Association for the Study of the Liver Terms and Conditions

Journal of Hepatology 2013 59, 1349-1353DOI: (10. 1016/j. jhep. 2013 Copyright © 2013 European Association for the Study of the Liver Terms and Conditions