Nitric Oxide in Human Skin: Current Status and Future Prospects Daniela Bruch-Gerharz , Thomas Ruzicka   Journal of Investigative Dermatology  Volume 110, Issue 1, Pages 1-7 (January 1998) DOI: 10.1046/j.1523-1747.1998.00084.x Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Biosynthesis of NO. NO is generated by a class of NADPH-dependent NO synthases, which catalyze the conversion of arginine to citrulline and NO with a 1:1 stoichiometry. Three different isoenzymes have been characterized: two of them are constitutive and calcium-/calmodulin-activated (ecNOS and ncNOS), and one is an inducible, calcium-independent isoform (iNOS). Journal of Investigative Dermatology 1998 110, 1-7DOI: (10.1046/j.1523-1747.1998.00084.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Dual pathway mechanisms of NO. The formation of NO and the subsequent regulatory and cytotoxic effects of NO in the intracellular and extracellular milieu are listed. Journal of Investigative Dermatology 1998 110, 1-7DOI: (10.1046/j.1523-1747.1998.00084.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Potential functions of NO in human skin.Schematic model of a “generic” cell of the skin showing the potential targets and biologic functions of NO in human skin. Journal of Investigative Dermatology 1998 110, 1-7DOI: (10.1046/j.1523-1747.1998.00084.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions