Volume 376, Issue 9737, Pages (July 2010)

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Volume 376, Issue 9737, Pages 259-266 (July 2010) Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial Prof David R McCance, FRCP, Valerie A Holmes, PhD, Michael JA Maresh, FRCOG, Christopher C Patterson, PhD, James D Walker, MD, Donald WM Pearson, FRCPE, Prof Ian S Young, FRCPath The Lancet Volume 376, Issue 9737, Pages 259-266 (July 2010) DOI: 10.1016/S0140-6736(10)60630-7 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile The Lancet 2010 376, 259-266DOI: (10.1016/S0140-6736(10)60630-7) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 2 PAI-1 to PAI-2 ratio by weeks' gestation PAI-1 to PAI-2 ratio in vitamin and placebo groups at baseline, 26 weeks', and 34 weeks' gestation (within 2 weeks). Boxes show IQRs, and medians are shown by horizontal lines. Vertical lines extend to the highest and lowest values, but outliers (results exceeding the upper quartile by more than 1·5 times the IQR) are identified as individual symbols. Values greater than 5 are shown by arrows at the top of the figure. PAI=plasminogen activator inhibitor. The Lancet 2010 376, 259-266DOI: (10.1016/S0140-6736(10)60630-7) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 3 Plasma ascorbate and serum α-tocopherol concentrations, by weeks' gestation Mean plasma ascorbate (A) and serum α-tocopherol (B) concentrations in vitamin and placebo groups at baseline, 26 weeks', and 34 weeks' gestation (within 2 weeks). Error bars show 95% CIs. The Lancet 2010 376, 259-266DOI: (10.1016/S0140-6736(10)60630-7) Copyright © 2010 Elsevier Ltd Terms and Conditions