Fig. 8 Analysis of bone structure within the soft and stiff scaffold.

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Fig. 8 Analysis of bone structure within the soft and stiff scaffold. Analysis of bone structure within the soft and stiff scaffold. (A and B) Backscattered scanning electron microscopy overview images of one sample each from the soft + shielding plate group (A) and the stiff + shielding plate group (B). (C to E) Woven bone formation as the “first wave” of critical size defect regeneration. Newly formed bone was characterized by a lower mineral content (darker gray scale). (F) Dense plexiform bone formation at the bone-scaffold interface characterized the “second wave” of critical size defect regeneration. Brighter (gray) areas show a higher degree of mineralization. (G) Bony integration of the Ti-mesh scaffold with plexiform bone, which had a lower mineral content in comparison to the adjacent cortical bone. (H) The higher magnifications of the cortical bone adjacent to the scaffold showed a reduction of the cortical bone density with Haversian remodeling. (I) Direct bone-scaffold contact. (A and B) Scale bars, 2 mm; (C to F) scale bars, 500 μm; (G) scale bar, 1 mm; and (H and I) scale bars, 500 μm. Anne-Marie Pobloth et al., Sci Transl Med 2018;10:eaam8828 Published by AAAS