Effects of β2-agonists on airway tone and bronchial responsiveness

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Presentation transcript:

Effects of β2-agonists on airway tone and bronchial responsiveness Michael J. Larj, MD, Eugene R. Bleecker, MD Journal of Allergy and Clinical Immunology Volume 110, Issue 6, Pages S304-S312 (December 2002) DOI: 10.1067/mai.2002.130045 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Changes in FEV1 with albuterol formulated with hydrofluoroalkane. Ventolin is albuterol formulated with chlorofluorocarbon. (From Bleecker ER, Tinkelman DG, Ramsdell J, et al. Proventil HFA provides bronchodilation comparable to ventolin over 12 weeks of regular use in asthmatics. Chest 1998;113:283-9. With permission.) Journal of Allergy and Clinical Immunology 2002 110, S304-S312DOI: (10.1067/mai.2002.130045) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 Effect of treatment with budesonide and terbutaline on bronchial responsiveness. (From Kraan J, Koëter GH, vd Mark TW, et al. Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: a comparison between budesonide and terbutaline. J Allergy Clin Immunol 1985;76:628-36. With permission.) Journal of Allergy and Clinical Immunology 2002 110, S304-S312DOI: (10.1067/mai.2002.130045) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 3 Tolerance to the bronchoprotective effects of inhaled salbutamol. (Data from Cockcroft DW, McParland CP, Britto SA, et al. Regular inhaled salbutamol and airway responsiveness to allergen. Lancet 1993;342:833-7.) Journal of Allergy and Clinical Immunology 2002 110, S304-S312DOI: (10.1067/mai.2002.130045) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 4 Prolonged effect of salmeterol against EIB. (From Kemp JP, Dockhorn RJ, Busse WW, et al. Prolonged effect of inhaled salmeterol against exercise-induced bronchospasm. Am J Respir Crit Care Med 1994;150:1612-5. With permission.) Journal of Allergy and Clinical Immunology 2002 110, S304-S312DOI: (10.1067/mai.2002.130045) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 5 Change in airway hyperresponsiveness over 24 weeks. MDI, Metered-dose inhaler. (Data from Rosenthal RR, Busse WW, Kemp JP, et al. Effect of long-term salmeterol therapy compared with as-needed albuterol use on airway hyperresponsiveness. Chest 1999;116:595-602.) Journal of Allergy and Clinical Immunology 2002 110, S304-S312DOI: (10.1067/mai.2002.130045) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 6 Effect of β2AR genotype on baseline pulmonary function. ANOVA, Analysis of variance. (Data from Summerhill E, Leavitt SA, Gidley H, et al. β2-Adrenergic receptor Arg16/Arg16 genotype is associated with reduced lung function, but not with asthma, in the Hutterites. Am J Respir Crit Care Med 2000;162:599-602.) Journal of Allergy and Clinical Immunology 2002 110, S304-S312DOI: (10.1067/mai.2002.130045) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 7 Comparison of response to albuterol QID or PRN by genotype. (From Israel E, Drazen JM, Liggett SB, et al. The effect of polymorphisms of the β2-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med 2000;162:75-80. With permission.) Journal of Allergy and Clinical Immunology 2002 110, S304-S312DOI: (10.1067/mai.2002.130045) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 8 Influence of β2AR polymorphisms on asthma exacerbations. (From Taylor DR, Drazen JM, Herbison GP, et al. Asthma exacerbations during long-term β agonist use: influence of β2 adrenoceptor polymorphism. Thorax 2000;55:762-7. With permission.) Journal of Allergy and Clinical Immunology 2002 110, S304-S312DOI: (10.1067/mai.2002.130045) Copyright © 2002 Mosby, Inc. Terms and Conditions