Effects of sodium nitroprusside on splanchnic microcirculation in a resuscitated porcine model of septic shock A. Assadi, O. Desebbe, C. Kaminski, T.

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Effects of sodium nitroprusside on splanchnic microcirculation in a resuscitated porcine model of septic shock A. Assadi, O. Desebbe, C. Kaminski, T. Rimmelé, F. Bénatir, J. Goudable, D. Chassard, B. Allaouchiche British Journal of Anaesthesia Volume 100, Issue 1, Pages 55-65 (January 2008) DOI: 10.1093/bja/aem278 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 Extracts of 120 s of ileal MBF tracing by LDF in arbitrary PU. Note the absence of respiratory oscillations and peristaltic artifacts. Flow motion oscillations are present with frequency of 4–6 min−1. British Journal of Anaesthesia 2008 100, 55-65DOI: (10.1093/bja/aem278) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 2 Extracts of hepatic MBF tracing by LDF in arbitrary PU. Respiratory oscillations are regular and constant throughout the experiment and slightly alter the signal amplitude. British Journal of Anaesthesia 2008 100, 55-65DOI: (10.1093/bja/aem278) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 3 Experimental protocol. Each animal received in a random succession, equal volumes of either SNP (5 μg kg−1 min−1) or NS for 30 min. British Journal of Anaesthesia 2008 100, 55-65DOI: (10.1093/bja/aem278) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 4 Extracts of typical (a) hepatic and (b) ileal MBF tracing by LDF in arbitrary PU. Relative MBF changes before, during continuous infusion of SNP, and after discontinuing drug administration. MBF increases during SNP administration and decreases after discontinuation. British Journal of Anaesthesia 2008 100, 55-65DOI: (10.1093/bja/aem278) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 5 (a) MAP, (b) CI, and (c) MPAP changes before drug administration. Sepsis was induced at T0 min, at T30 min=data during hypodynamic shock, at T60 min=data after resuscitation to convert hypodynamic shock to normodynamic shock. At T120 min, pigs were stabilized 60 min before drug administration. Data are presented as median (inter-quartile range). *P<0.05 (different from baseline). British Journal of Anaesthesia 2008 100, 55-65DOI: (10.1093/bja/aem278) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 6 (a) Ileal and (b) hepatic MBF changes before drug administration. Sepsis was induced at T0 min; at T30 min resuscitation converted hypodynamic shock to normodynamic shock. At T120 min, pigs were stabilized for 60 min before drug administration. All MBFs were set at 100% at T0 min and values were expressed as percentage of baseline. British Journal of Anaesthesia 2008 100, 55-65DOI: (10.1093/bja/aem278) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 7 Relative (a) ileal and (b) hepatic MBF changes during drug administration. Endotoxic pigs were resuscitated with either SNP or NS (control). Relative changes before, during continuous infusion, and 30 min after discontinuing administration of the test drug. All MBFs were set at 100% before administration of the test drug. MBFs were expressed as percentage of their values before drug administration. (c) Individual ileal MBF during SNP infusion. *P<0.05 (significant difference between values, before and after drug administration); #P<0.05 (significant difference from control). British Journal of Anaesthesia 2008 100, 55-65DOI: (10.1093/bja/aem278) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 8 Relative changes of (a) CI, (b) fluid replacement, and (c) norepinephrine infusions during drug administration. Endotoxic pigs were resuscitated with either SNP or NS (control). Relative changes before, during continuous infusion, and 30 min after discontinuing administration of the test drug. *P<0.05 (significant difference between values before and after drug administration); #P<0.05 (significant difference from control). British Journal of Anaesthesia 2008 100, 55-65DOI: (10.1093/bja/aem278) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 9 Relationship between MBF and CI variables in endotoxic pigs during SNP infusion. (a) There is a poor correlation between ileal MBF and CI (r2=0.49, P=0.007); (b) there is no correlation between hepatic MBF and CI (r2=0.26, P=0.07). MBFs were expressed as percentage of their values, between before and after SNP administration. CI, cardiac index. British Journal of Anaesthesia 2008 100, 55-65DOI: (10.1093/bja/aem278) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions