Nat. Rev. Neurol. doi: /nrneurol

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Nat. Rev. Neurol. doi:10.1038/nrneurol.2017.81 Figure 4 Estimated lymphoablative and myeloablative effects of AHSCT protocols for multiple sclerosis Figure 4 | Estimated lymphoablative and myeloablative effects of AHSCT protocols for multiple sclerosis. The expected relative lymphoablative and myeloablative effects in different conditioning protocols used in autologous haematopoietic stem cell transplantation (AHSCT) are depicted. Quantitative metrics are unavailable, and the size of the circles indicates the error in the estimates and the variability of the effects attainable in different patients. The dotted line represents the threshold of the myeloablative effect, above which haematopoietic stem cell (HSC) support is required for haematopoietic recovery and patient survival; in most patients treated with protocols below this threshold, haematopoiesis can recover without HSC transplantation, albeit with a longer recovery interval. These protocols are, therefore, considered non-myeloablative68. Muraro, P. A. et al. (2017) Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis Nat. Rev. Neurol. doi:10.1038/nrneurol.2017.81