Volume 59, Issue 6, Pages (June 2001)

Slides:

Advertisements

Similar presentations

Volume 57, Issue 2, Pages (October 2000)

Advertisements

Bioengineered vascular access maintains structural integrity in response to arteriovenous flow and repeated needle puncture Bryan W. Tillman, MD, PhD,

Wound healing around and within saphenous vein bypass grafts

Neointimal hyperplasia associated with synthetic hemodialysis grafts

Volume 85, Issue 2, Pages (January 2014)

Chronic kidney disease aggravates arteriovenous fistula damage in rats

Volume 56, Issue 3, Pages (September 1999)

Volume 62, Issue 6, Pages (December 2002)

Fariba Chalajour, MD, Laura A

Reconstruction of pulmonary artery with porcine small intestinal submucosa in a lamb surgical model: Viability and growth potential Lorenzo Boni, MD,

Lysyl oxidase expression in a rat model of arterial balloon injury

VEGF Gene Delivery to Muscle

Volume 9, Issue 5, Pages (May 2004)

Vascular anastomoses with laser energy

Experimental noninferiority trial of synthetic small-caliber biodegradable versus stable vascular grafts Damiano Mugnai, MD, Jean-Christophe Tille, MD,

K.M. Schumacher, S.C. Phua, A. Schumacher, J.Y. Ying

Lipoplex gene transfer of inducible nitric oxide synthase inhibits the reactive intimal hyperplasia after expanded polytetrafluoroethylene bypass grafting

Boundary layer infusion of heparin prevents thrombosis and reduces neointimal hyperplasia in venous polytetrafluoroethylene grafts without systemic anticoagulation

Basic fibroblast growth factor slow release stent graft for endovascular aortic aneurysm repair: A canine model experiment Masaki Kajimoto, MD, Takatsugu.

Breast arterial calcification in chronic kidney disease: absence of smooth muscle apoptosis and osteogenic transdifferentiation W. Charles O'Neill, Amy.

Volume 62, Issue 6, Pages (December 2002)

The role of circulating cells in the healing of vascular prostheses

Long-term patency of small-diameter vascular graft made from fibroin, a silk-based biodegradable material Soichiro Enomoto, MD, PhD, Makoto Sumi, MD,

Volume 57, Issue 2, Pages (October 2000)

Long-term reduction of medial and intimal thickening in porcine saphenous vein grafts with a polyglactin biodegradable external sheath Vikram Vijayan,

Alex Westerband, MD, Joseph L. Mills, MD, John M. Marek, MD, Ronald L

Volume 69, Issue 7, Pages (April 2006)

Volume 57, Issue 2, Pages (October 2000)

An “off the shelf” vascular allograft supports angiogenic growth in three-dimensional tissue engineering Johann M. Zdolsek, MD, Wayne A. Morrison, MB.

Paclitaxel coating of the luminal surface of hemodialysis grafts with effective suppression of neointimal hyperplasia Insu Baek, MS, Cheng Zhe Bai, PhD,

Conformational stress and anastomotic hyperplasia

J.-S. Chiu, J.-E. Tzeng, Y.-F. Wang

Volume 74, Issue 1, Pages (July 2008)

Adventitial endothelial implants reduce matrix metalloproteinase-2 expression and increase luminal diameter in porcine arteriovenous grafts Helen M.

Role of hemodynamic forces in the ex vivo arterialization of human saphenous veins Xavier Berard, MD, PhD, Sébastien Déglise, MD, Florian Alonso, PhD,

Vein graft failure Journal of Vascular Surgery

A self-renewing, tissue-engineered vascular graft for arterial reconstruction Kei Torikai, MD, Hajime Ichikawa, MD, PhD, Koichiro Hirakawa, MS, Goro Matsumiya,

The temporal relationship between the development of vein graft intimal hyperplasia and growth factor gene expression John R. Hoch, MD, Vida K. Stark,

Dacron inhibition of arterial regenerative activities

Hepatocyte growth factor prevents intimal hyperplasia in rabbit carotid expanded polytetrafluoroethylene grafting Masakazu Harada, MD, Hiroaki Takenaka,

Dimensional analysis of human saphenous vein grafts: Implications for external mesh support Paul Human, PhD, Thomas Franz, PhD, Jacques Scherman, MBChB,

The molecular mechanisms of hemodialysis vascular access failure

Distinct macrophage phenotype and collagen organization within the intraluminal thrombus of abdominal aortic aneurysm Jayashree Rao, MS, Bryan N. Brown,

Clifford M. Sales, MD, Michael L. Marin, MD, Frank J

Steven S. Weber, MD, Alan J. Annenberg, MD, Creighton B

Tao Lin, Catherine Horsfield, Michael G. Robson Kidney International

Lisheng Zhang, MD, Leigh Brian, MS, Neil J. Freedman, MD

Volume 74, Issue 11, Pages (December 2008)

Photodynamic therapy of vein grafts: Suppression of intimal hyperplasia of the vein graft but not the anastomosis Glenn M. LaMuraglia, MD, Michael L.

Volume 69, Issue 12, Pages (June 2006)

Antisense basic fibroblast growth factor alters the time course of mitogen-activated protein kinase in arterialized vein graft remodeling Akimasa Yamashita,

Immunolocalization and temporal distribution of cytokine expression during the development of vein graft intimal hyperplasia in an experimental model

Morphologic characteristics of varicose veins: possible role of metalloproteinases Kenneth J Woodside, MD, Mingdao Hu, MD, Ann Burke, MS, Maki Murakami,

Impact of endothelial cell seeding on long-term patency and subendothelial proliferation in a small-caliber highly porous polytetrafluoroethylene graft

Influence of vein valves in the development of arteriosclerosis in venoarterial grafts in the rabbit Aurelio Chaux, MDa (by invitation), Xin Min Ruan,

Of veins, valves, and vascular access!

Robert A. McCready, M. D. , Margaret A. Price, B. S. , Richard J

Volume 84, Issue 2, Pages (August 2013)

Neointimal hyperplasia on a cell-seeded polytetrafluoroethylene graft is promoted by transfer of tissue plasminogen activator gene and inhibited by transfer.

Vein interposition cuffs decrease the intimal hyperplastic response of polytetrafluoroethylene bypass grafts Mark Kissin, MD, Nikhil Kansal, MD, Peter.

Blockade of monocyte chemoattractant protein-1 by adenoviral gene transfer inhibits experimental vein graft neointimal formation Hideki Tatewaki, MD,

Early Fistula Failure: Back to Basics

The vascular secret of Klotho

Y. Castier, S. Lehoux, Y. Hu, G. Fonteinos, A. Tedgui, Q. Xu

Richard L. Binns, MD Journal of Vascular Surgery

Volume 57, Issue 2, Pages (October 2000)

Effect of Vein Graft Harvesting on Endothelial Nitric Oxide Synthase and Nitric Oxide Production Michael R. Dashwood, PhD, Kay Savage, PhD, Audrey Dooley,

Neointimal formation at the sites of anastomosis of the internal thoracic artery grafts after coronary artery bypass grafting in human subjects: An immunohistochemical.

Volume 87, Issue 6, Pages (June 2015)

Prevention of stenosis after vascular reconstruction: Pharmacologic control of intimal hyperplasia—A review Alexander W. Clowes, MD, Michael A. Reidy,

Presentation transcript:

Volume 59, Issue 6, Pages 2325-2334 (June 2001) Venous neointimal hyperplasia in polytetrafluoroethylene dialysis grafts Prabir Roy-Chaudhury, Burnett S. Kelly, Mary Ann Miller, Anita Reaves, Janice Armstrong, Nuwan Nanayakkara, Sue C. Heffelfinger Kidney International Volume 59, Issue 6, Pages 2325-2334 (June 2001) DOI: 10.1046/j.1523-1755.2001.00750.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Diagrammatic representation of the venous anastomosis to demonstrate how the sections were cut. Maximal neointimal hyperplasia occurred at the site of the graft-vein anastomosis (B) and in the downstream vein (A). Kidney International 2001 59, 2325-2334DOI: (10.1046/j.1523-1755.2001.00750.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Scoring scale for angiogenesis (microvessel formation). (a) (vWF ×300, neointima) A single microvessel (score = 1+). (b) (vWF ×300, neointima) A few scattered microvessels (score 2+). (c) (vWF ×300, adventitia) A large number of microvessels (score 3+). (d) (vWF ×300, adventitia) Density of microvessels needed to have a score of 4+. Kidney International 2001 59, 2325-2334DOI: (10.1046/j.1523-1755.2001.00750.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Normal vein. (a) Note the thin one- to two-layer intima (thin arrows) and three- to four-layer media (thick arrows) of normal vein (hematoxylin and eosin ×400). (b) Relative absence of endothelial cell staining in the adventitia and media of normal vein. Note the intense staining of the single layer endothelium (vWF ×1500). (c) Thickness of normal venous (between thin arrows, V) and arterial (double-headed arrow, A) intima media (SMA ×117). (d) Thickness of the venous neointima and media in a dialysis patient with venous stenosis (SMA ×117). At an identical magnification to (c), the venous neointima (d; double-headed arrow, N) is 20 times thicker than the intima media of normal vein (c; between thin arrows). Also, note that the venous media (d; M, length of bar) is as thick as the arterial media in (c), indicating arterialization of the vein. Kidney International 2001 59, 2325-2334DOI: (10.1046/j.1523-1755.2001.00750.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 4 Cell types and cytokines (adventitia to left and lumen to right). (a) PTFE graft (hematoxylin and eosin ×200). Note the significant venous neointimal hyperplasia (extent of arrow) between the graft (G) and the lumen (L). (b) Downstream vein (hematoxylin and eosin ×200). Note the presence of microvessels (thin arrows) within the adventitia (A). Also note the thickened (arterialized) media (M, double-headed arrow) and the significant amount of neointimal hyperplasia (N, bar). (c) Downstream vein; neointima (vWf ×400). Note the prominent angiogenesis within the neointima (arrows), as assessed by this endothelial cell marker (d) downstream vein; neointima (vWF + Ki67 ×800). High-power view of a microvessel within the neointima of downstream vein. Note the distinct colocalization of blue (endothelial) and brown (proliferating) cells indicating active endothelial cell proliferation (angiogenesis). (e) Upstream graft; neointima (PG-M1 ×2000). High-power view of a macrophage giant cell adjacent to the neointimal surface of PTFE graft (G). Also note the large number of macrophages in this area (thin arrows). (f) Downstream vein; neointima (SMA + Ki-67 ×1000). High-power view of a portion of the neointima stained for smooth muscle cells (brown) and proliferating cells (blue). Note that almost all the active cellular proliferation in this specimen (arrows) is occurring within the neointimal microvessels (angiogenesis). At the time that this specimen was harvested, there was no ongoing smooth muscle cell proliferation (g) PTFE graft; adventitia (bFGF ×500). Note the strong expression of bFGF in adventitial vessels (thick arrow) and by the macrophage giant cell layer (thin arrow) lining the graft. (f) Downstream vein; media and neointima (PDGF ×400). There is strong expression of this cytokine in the venous media (M) and by smooth muscle cells/myofibroblasts within the neointima (N, bar). Kidney International 2001 59, 2325-2334DOI: (10.1046/j.1523-1755.2001.00750.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 5 Matrix and structural proteins. (a) PTFE graft (tenascin ×200). There is strong expression of tenascin in the region of the macrophage giant cell layer (thin arrow) surrounding PTFE graft (G) and on the abluminal side of the neointima (thick arrow). (b) PTFE graft (collagen IV ×160). Collagen is present as expected within the walls of prominent adventitial blood vessels (thin arrows) and in this particular sample within the luminal portion of the neointima (thick arrow). (c) Downstream vein; neointima (fibronectin ×500). There is strong diffuse expression of fibronectin by ECM components. (d) Downstream vein; neointima (laminin ×500). Laminin is a prominent component of microvessels (arrows) within the neointima. Kidney International 2001 59, 2325-2334DOI: (10.1046/j.1523-1755.2001.00750.x) Copyright © 2001 International Society of Nephrology Terms and Conditions