Human Skin Explants Recapitulate Key Features of HSV-1 Infections Megan H. Orzalli  Journal of Investigative Dermatology  Volume 139, Issue 3, Pages 519-521 (March 2019) DOI: 10.1016/j.jid.2018.09.015 Copyright © 2018 The Author Terms and Conditions

Figure 1 HSV-1 productively infects abdominal skin after perturbation with a microneedle roller. HSV-1 infection results in decreased nectin 1 expression and increased accumulation of nuclear NF-κB and IRF3. Virus replication in the skin is inhibited by antiviral drugs. HSV-1, herpes simplex virus type 1. Journal of Investigative Dermatology 2019 139, 519-521DOI: (10.1016/j.jid.2018.09.015) Copyright © 2018 The Author Terms and Conditions